BC Innovations | Jan 4, 2018
Translation in Brief

New Therapeutic Targets and Biomarkers: December 2017

New Therapeutic Targets and Biomarkers: December 2017 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database during December 2017. Therapeutic targets are defined as any protein, gene or other...
BC Innovations | Dec 13, 2017
Distillery Therapeutics

Cardiovascular

INDICATION: Atherosclerosis Mouse studies suggest inhibiting ARHGEF1 could help treat atherosclerosis. In an LDLR-deficient mouse model of atherosclerosis, ARHGEF1 knockout decreased the formation of atherosclerotic lesions compared with normal expression. In two bone marrow-ablated, LDLR-deficient...
BC Innovations | Jun 20, 2013
Cover Story

Interfacing with Ras

A German team has identified a compound that disrupts a protein-protein interaction that localizes K-Ras to the cell membrane, thus inhibiting tumor growth. 1 The interface provides a new small molecule binding site for the...
BC Innovations | Feb 14, 2013
Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer Ras homolog gene family member A (RHOA); leukemia-associated Rho guanine nucleotide exchange factor (LARG) In vitro studies identified a small molecule inhibitor of the...
BC Innovations | Feb 19, 2009
Distillery Therapeutics

Indication: Cancer

This week in therapeutics Indication Target/ marker/pathway Summary Licensing status Publication and contact information Cancer Cancer Coiled-coil domain containing 88A (CCDC88A; GIV); Rho guanine nucleotide exchange factor (GEF; ARHGEF); G protein alpha inhibiting activity polypeptide...
BC Innovations | Jun 5, 2008
Distillery Therapeutics

This Week in Therapeutics

This week in therapeutics Indication Target/ marker/pathway Summary Licensing status Publication and contact information Musculoskeletal disease Osteoporosis Rho guanine nucleotide exchange factor (GEF) 3 (ARHGEF3) A genome-wide association study suggests that ARHGEF3 plays a role...
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