BioCentury | Jan 22, 2015
Distillery Therapeutics

Therapeutics: Rho family GTPase 1 (RND1)

...Cancer INDICATION: Breast cancer Mouse studies suggest modulating the Ras signaling suppressor RND1 could help prevent... prevent breast cancer metastasis. In a mouse model of mammary cancer, shRNA knockdown of RND1...
...Ras signaling pathway, could be effective in other mouse models of RND1 deficiency-driven tumorigenesis. TARGET/MARKER/PATHWAY: Rho family GTPase 1 (RND1)...
BioCentury | Apr 11, 2013
Targets & Mechanisms

RaPID results

A Japanese team has provided new structural insights into the function of a conserved class of drug transporters and has identified cyclic peptide inhibitors of one such protein. 1 The researchers are now collaborating with...
BioCentury | May 14, 2009
Targets & Mechanisms

Going after GEFs in cancer

Despite the association between mutations in Rho guanine nucleotide exchange factors and cancer, no companies are pursuing GEF inhibitors. Antagonizing the targets is challenging because it requires inhibiting a protein-protein interaction, a task for which...
BioCentury | Mar 31, 2003

Venture gap widens

Venture gap widens Although the size of the average venture round has softened over the past 15 months, the top quartile of rounds is capturing an ever greater share of the money. Indeed, the difference...
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