14:45 , Mar 19, 2019 |  BC Innovations  |  Distillery Therapeutics

RGMA protein to treat peritonitis

DISEASE CATEGORY: Inflammation INDICATION: Inflammation Patient sample and mouse studies suggest RGMA could help treat peritonitis. In plasma samples from pediatric patients with intra-abdominal hypertension, a condition associated with peritonitis, levels of RGMA were higher...
20:42 , Oct 31, 2017 |  BC Innovations  |  Distillery Techniques

Disease models

TECHNOLOGY: Animal models Mice overexpressing RGMA could be useful for screening therapies to treat PD. In mice, a neuron-targeting adeno-associated viral (AAV) vector encoding RGMA recapitulated the motor deficits, tremors, dopaminergic neuron loss and high...
07:00 , Apr 21, 2011 |  BC Innovations  |  Distillery Therapeutics

Indication: Inflammation

Indication Target/marker/pathway Summary Licensing status Publication and contact information Inflammation Inflammation RGM domain family member A (RGMA) In vitro and mouse studies suggest that RGMA impedes leukocyte migration and could thus help treat inflammatory conditions....
07:00 , Mar 31, 2011 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Multiple sclerosis (MS) RGM domain family member A (RGMA) Patient sample and mouse studies suggest that inhibiting RGMA could help treat...