BioCentury | Dec 12, 2019
Tools & Techniques

New hepatic stellate cell subset drives liver fibrosis

...and diabetic nephropathy. Targets LPAR1 (EDG2; LPA1) - Lysophosphatidic acid receptor 1 RXRA (RXRα) - Retinoid X receptor...
BioCentury | Jan 3, 2019
Distillery Therapeutics

Cancer

...RXR agonist, for cutaneous T cell lymphoma (CTCL). Io Therapeutics Inc. has IRX4204, a selective pan-RXR...
...KGaA has BBI-3000, an oral RXR agonist, in preclinical studies to treat CTCL. TARGET/MARKER/PATHWAY: Retinoid X receptor (RXR...
...Dipanjan Pan, University of Illinois at Urbana-Champaign, Champaign, Ill. email: dipanjan@illinois.edu Jennie Walters University of Illinois Urbana-Champaign Retinoid X receptor (RXR) Sarcoma...
BioCentury | Jul 25, 2018
Distillery Therapeutics

Cancer

...INDICATION: Melanoma Cell culture and mouse studies suggest inhibiting RXR could help treat melanoma. In a...
...colorectal cancer and solid tumors and preclinical studies for acute lymphoblastic leukemia (ALL). TARGET/MARKER/PATHWAY: Retinoid X receptor (RXR...
...University Leuven Japan Tobacco Inc. Novartis AG BRAF MAP kinase kinase 1 (MAP2K1) (MEK1) MAP kinase kinase 2 (MAP2K2) (MEK2) Retinoid X receptor (RXR...
BioCentury | Jul 13, 2018
Preclinical News

RXR a potential minimal residual disease target in melanoma

...New research into the biology of solid tumor minimal residual disease (MRD) has revealed retinoid X receptor (RXR...
...RXR gamma (RXRG; RXRgamma) directly targets most neural crest stem cell markers and suggested liganded RXR...
...doublet. Jaime De Leon Catholic University Leuven BRAF MAP kinase kinase 1 (MAP2K1) (MEK1) MAP kinase kinase 2 (MAP2K2) (MEK2) MEK Retinoid X receptor (RXR) Retinoid X receptor...
BioCentury | Oct 27, 2016
Distillery Therapeutics

Cancer

...colorectal cancer cell line identified 10 compounds that agonized RXR homodimerization - a requirement for RXR...
...line-based transcription assays, seven of the compounds increased RXR -dependent transcription and nine increased the RXR...
...cancer, traumatic brain injury (TBI), Alzheimer’s disease (AD) and Parkinson’s disease (PD). TARGET/MARKER/PATHWAY: Retinoid X receptor ( RXR...
BioCentury | Sep 15, 2016
Targets & Mechanisms

KOR-recting MS

...protein 1 (LINGO-1) Anti-LINGO mAb Biogen Inc. (NASDAQ:BIIB) Antibody Phase II IRX4204 Retinoid X receptor (RXR) Selective pan-RXR...
BioCentury | Feb 25, 2016
Strategy

Changing the channel

...University School of Medicine. Landreth's study used a mouse model of AD, and showed the RXR...
...did not respond to requests for comment. At least one other company is developing an RXR...
...GPR21 - G protein-coupled receptor 21 RABGAP1 - RAB GTPase activating protein 1 RXR - Retinoid X receptor...
BioCentury | Aug 17, 2015
Company News

Mylan sales and marketing update

...systemic therapy. Bexarotene is a generic version of Targretin , an oral selective retinoid X receptor ( RXR...
BioCentury | Jul 23, 2015
Distillery Therapeutics

Therapeutics: Peroxisome proliferation activated receptor (PPAR) α; retinoid X receptor (RXR)

...Alzheimer's disease (AD) In vitro and mouse studies suggest agonists of PPARα and its co-activator RXR...
...normal PPARα expression. In hippocampal neurons from normal mice, the PPARα agonist gemfibrozil or the RXR...
...for coronary artery disease (CAD) and hypercholesterolemia. TARGET/MARKER/PATHWAY: Peroxisome proliferation activated receptor (PPAR) α; retinoid X receptor (RXR...
BioCentury | Jul 16, 2015
Distillery Therapeutics

Therapeutics: Retinoid X receptor (RXR)

...Alzheimer's disease (AD) In vitro and mouse studies suggest combining docosahexaenoic acid (DHA) and the RXR...
...kinase C (PKC) ε ( PKCE ), in preclinical testing to treat AD. TARGET/MARKER/PATHWAY: Retinoid X receptor (RXR...
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