BioCentury | May 29, 2020
Management Tracks

Leaving Sanofi, Loew to guide Ipsen’s path forward for troubled musculoskeletal program

...will join the executive committee. Targets ALK2 (ACVR1) - Activin receptor-like kinase 2 RARG - Retinoic acid receptor...
BioCentury | Jan 24, 2020
Clinical News

Ipsen’s $1B bet on Clementia fizzles with FOP trial stop

...$5.4 billion in market cap. Targets: ALK2 (ACVR1) - Activin receptor-like kinase 2; RARG - Retinoic acid receptor...
BioCentury | Dec 20, 2019
Emerging Company Profile

Centaurus: inhibiting ceramide synthesis for cardiometabolic disease

...with SNPs in DEGS1 are otherwise healthy. Additionally, the retinoid fenretinide, a DEGS1 inhibitor and RAR...
...issued Targets CERS6 (LASS6) - Ceramide synthase 6 DEGS1 - δ-4-desaturase sphingolipid 1 RAR - Retinoic acid receptor Hongjiang...
BioCentury | Dec 6, 2019
Company News

FDA hold muddies Ipsen’s timeline for palovarotene in rare bone disease

...Targets: ALK2 (ACVR1) - Activin receptor-like kinase 2; RARG - Retinoic acid receptor γ Paul Bonanos, Associate Editor Ipsen Group Retinoic acid receptor...
BioCentury | Oct 17, 2019
Clinical News

Syros prioritizing oral CDK7, dropping IV after Phase I data

...million in cash at June 30. Targets: CDK7 - Cyclin dependent kinase 7; RARA - Retinoic acid receptor...
BioCentury | Oct 16, 2019
Company News

Ipsen doubles down on rare musculoskeletal disease via Blueprint deal

...$0.87 to $73.62 on Wednesday. Targets: ALK2 (ACVR1) - Activin receptor-like kinase 2; RARG - Retinoic acid receptor...
BioCentury | May 7, 2019
Distillery Techniques

Expression of multigene panels in CNS cell types as markers of early AD

...fibrillary acidic protein (GFAP) in astrocytes. Down-regulated genes included synaptosomal-associated protein 25 (SNAP25) in oligodendrocytes, RAR-related...
...protein (GFAP) Leucine rich repeat and Ig domain containing 1 (LINGO1) Potassium voltage-gated channel interacting protein 1 (KCNIP1) RAR-related...
BioCentury | Mar 26, 2019
Distillery Therapeutics

The short-chain fatty acid pentanoate for MS

...expression of the anti-inflammatory cytokine IL-10 and decreased expression of pro-inflammatory genes, including IL-21 and RAR-related...
BioCentury | Mar 25, 2019
Distillery Therapeutics

Inhibiting RAR for retinitis pigmentosa

...DISEASE CATEGORY: Ophthalmic disease INDICATION: Retinitis Mouse studies suggest inhibiting RAR could help treat retinitis pigmentosa...
...Therapeutics inc. has IRX4310, a pan-RAR antagonist, in Phase I testing for neutropenia. TARGET/MARKER/PATHWAY: Retinoic acid receptor (RAR...
...Richard H. Kramer, University of California Berkeley, Berkeley, Calif. email: rhkramer@berkeley.edu Claire Quang University of California Berkeley Retinoic acid receptor (RAR) Retinitis...
BioCentury | Mar 1, 2019
Company News

Clementia takeout to bolster Ipsen’s orphan pipeline

...Clementia shares rose $11.12 (74%) to $26.06 on Feb. 25. Palovarotene is a small molecule retinoic acid receptor...
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