BioCentury | Jul 10, 2018
Distillery Therapeutics

Cancer

...In vitro , cell culture and mouse studies identified a SALL4-derived peptide inhibitor of the SALL4-RBBP4...
...as adjuvant therapy for high-risk HCC. TARGET/MARKER/PATHWAY: Spalt like transcription factor 4 (SALL4); retinoblastoma binding protein 4 (RBBP4; RBAP48...
...of Singapore, Singapore email: daniel.tenen@nus.edu.sg Claire Quang Brigham and Women's Hospital Harvard Medical School National University of Singapore Retinoblastoma binding protein 4 (RBBP4) (RBAP48) Spalt...
BioCentury | Apr 10, 2018
Distillery Techniques

Drug platforms

TECHNOLOGY: Gene therapy CRISPR-based gene editing with an engineered Cas9-based fusion protein that enhances homology-dependent repair (HDR) could enable greater integration of therapeutic genes than standard Cas9. The system utilizes an engineered enzyme consisting of...
BioCentury | Mar 10, 2017
Targets & Mechanisms

Poly drugs for polycomb

...consists of five subunits: the three core enzyme-related proteins, EED , EZH2 and SUZ12 ; RBBP4...
...and AT-Rich interaction domain containing 2; PRC2 - polycomb repressive complex 2; RBBP4 (RBAP48) - Retinoblastoma binding protein 4...
BioCentury | Sep 26, 2013
Distillery Therapeutics

Indication: Neurology

...information Neurology Cognitive dysfunction Retinoblastoma binding protein 4 (RBBP4; RBAP48) Studies in patient samples and mice suggest increasing RBAP48...
...tissue samples showed that RBAP48 levels decreased with age. In young transgenic mice, inhibition of Rbap48...
...in the dentate gyrus impaired performance on memory tasks. In aged mice, lentiviral expression of Rbap48...
BioCentury | Apr 22, 2010
Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Aneurysm Cyclin M2 (CNNM2); retinoblastoma binding protein 8 (RBBP8); StAR-related lipid transfer domain containing 13 (STARD13) A genomewide association study identified three SNPs that could...
BioCentury | Apr 16, 2009
Cover Story

Probing the character of proteins

A team from The Scripps Research Institute has developed a high throughput technology that can screen compound libraries against proteins whose biochemical activities are poorly characterized. 1 The method, which relies on fluorescent activity-based chemical...
BioCentury | Dec 11, 2008
Distillery Therapeutics

This week in therapeutics

...information Autoimmune disease Sjögren's syndrome Retinoblastoma binding protein 4 (RBBP4; RBAP48) A study in mice suggests that inhibiting RBAP48...
...autoimmune disease of the salivary and lacrimal glands. In adult mice, selective overexpression of human RBAP48...
...saliva than that seen in wild-type mice. Next steps include evaluating the preventative effects of RBAP48-targeting...
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