BioCentury | May 1, 2020
Distillery Therapeutics

The lipids LXA4 and RvD1 as treatment for E. coli pneumonia

DISEASE CATEGORY: Infectious disease INDICATION: Escherichia; pneumonia The lipids LXA4 and RvD1, ligands of the membrane receptor FPRL1, could treat E. coli pneumonia by promoting antibacterial functions in neutrophils. The release of neutrophil elastase, induced...
BioCentury | Sep 18, 2019
Distillery Therapeutics

Treating Parkinson's with the resolvin RvD1

DISEASE CATEGORY: Neurology INDICATION: Parkinson's disease (PD) The resolvin RvD1, a metabolite of omega-3 fatty acids, could treat Parkinson’s disease by preventing inflammation in the brain. CSF and plasma levels of RvD1 were lower in...
BioCentury | Jul 25, 2019
Translation in Brief

New Therapeutic Targets and Biomarkers: June 2019

New Therapeutic Targets and Biomarkers: June 2019 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database in June. Therapeutic targets are defined as any protein, gene or other molecule...
BioCentury | Jun 27, 2019
Distillery Therapeutics

Ketorolac and resolvins to prevent cancer recurrence

...Cancer, lung cancer, lymphoma, melanoma, colorectal cancer The generic COX inhibitor ketorolac and/or the resolvins RvD2...
...In a mouse model of LLC with surgical resection of primary tumors, pretreatment with ketorolac, RvD2...
...survival and reduced the number of lung micrometastases. Pretreatment with a combination of ketorolac and RvD2...
BioCentury | Dec 5, 2017
Distillery Therapeutics

Cancer

...INDICATION: Solid tumors Cell culture and mouse studies suggest RvD1, RvD2 and RvE1 could help treat...
...model of lung cancer and a xenograft model of pancreatic cancer, intraperitoneal injection of RvD1, RvD2...
...any agent alone. In mouse models of metastatic lung cancer and metastatic melanoma, RvD1 or RvD2...
BioCentury | Nov 30, 2017
Preclinical News

Resolvins keep tumor debris from stimulating tumor growth

...was dependent on the presence of macrophages. Panigrahy's team showed efficacy for resolvin D1 (RvD1), resolvin D2 (RvD2)...
...Leviten Auven Therapeutics Management LLLP Beth Israel Deaconess Medical Center Brigham and Women's Hospital Harvard Medical School Resolvyx Pharmaceuticals Inc. Resolvin D1 Resolvin D2 (RvD2) Resolvin...
BioCentury | Nov 9, 2016
Distillery Therapeutics

Cardiovascular

INDICATION: Atherosclerosis Patient sample and mouse studies suggest RvD1 could help treat atherosclerosis. In carotid artery tissue samples from patients undergoing endarterectomy, levels of RvD1 were lower in unstable atherosclerotic plaques than in stable plaques...
BioCentury | Oct 27, 2016
Distillery Therapeutics

Neurology

INDICATION: Guillain-Barré syndrome (GBS) Mouse studies suggest RvD1 could help treat the acute inflammatory demyelinating polyneuropathy (AIDP) subtype of GBS. In a mouse model of AIDP, intraperitoneal RvD1 decreased demyelination of sciatic nerves and disease...
BioCentury | Sep 3, 2015
Distillery Therapeutics

Therapeutics: Influenza A virus hemagglutinin (HA)

Infectious disease INDICATION: Influenza virus In vitro and mouse studies identified a broadly neutralizing antibody (bNAb) that could help treat influenza or design cross-reactive vaccines. The bNAb targeting the stem region of HA was isolated...
BioCentury | May 31, 2012
Distillery Therapeutics

Indication: Infectious disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease Bacterial infections Resolvin D1 (RvD1); RvD5 A study in mice suggests RvD1 and RvD5 could be useful for treating bacterial infections. In a mouse...
Items per page:
1 - 10 of 17