BioCentury | May 1, 2020
Distillery Therapeutics

The lipids LXA4 and RvD1 as treatment for E. coli pneumonia

DISEASE CATEGORY: Infectious disease INDICATION: Escherichia; pneumonia The lipids LXA4 and RvD1, ligands of the membrane receptor FPRL1, could treat E. coli pneumonia by promoting antibacterial functions in neutrophils. The release of neutrophil elastase, induced...
BC Innovations | Sep 18, 2019
Distillery Therapeutics

Treating Parkinson's with the resolvin RvD1

DISEASE CATEGORY: Neurology INDICATION: Parkinson's disease (PD) The resolvin RvD1, a metabolite of omega-3 fatty acids, could treat Parkinson’s disease by preventing inflammation in the brain. CSF and plasma levels of RvD1 were lower in...
BC Innovations | Dec 5, 2017
Distillery Therapeutics


INDICATION: Solid tumors Cell culture and mouse studies suggest RvD1, RvD2 and RvE1 could help treat solid tumors. In a mouse model of lung cancer and a xenograft model of pancreatic cancer, intraperitoneal injection of...
BC Extra | Nov 30, 2017
Preclinical News

Resolvins keep tumor debris from stimulating tumor growth

In an article published in the Journal of Experimental Medicine , researchers at Beth Israel Deaconess Medical Center and colleagues showed that resolvins, a class of lipids, can suppress the pro-cancer activity of tumor debris generated...
BC Innovations | Nov 9, 2016
Distillery Therapeutics


INDICATION: Atherosclerosis Patient sample and mouse studies suggest RvD1 could help treat atherosclerosis. In carotid artery tissue samples from patients undergoing endarterectomy, levels of RvD1 were lower in unstable atherosclerotic plaques than in stable plaques...
BC Innovations | Oct 27, 2016
Distillery Therapeutics


INDICATION: Guillain-Barré syndrome (GBS) Mouse studies suggest RvD1 could help treat the acute inflammatory demyelinating polyneuropathy (AIDP) subtype of GBS. In a mouse model of AIDP, intraperitoneal RvD1 decreased demyelination of sciatic nerves and disease...
BC Innovations | May 31, 2012
Distillery Therapeutics

Indication: Infectious disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease Bacterial infections Resolvin D1 (RvD1); RvD5 A study in mice suggests RvD1 and RvD5 could be useful for treating bacterial infections. In a mouse...
BC Innovations | Apr 22, 2010
Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Pain Resolvin E1 (RvE1); resolvin D1 (RvD1); cyclooxygenase-2 (COX-2) Studies in mice suggest that resolvins could help treat inflammatory pain. In mouse models of chemically...
BC Innovations | Apr 22, 2010
Targets & Mechanisms

Promoting pain resolution

Harvard Medical School researchers have shown that resolvins could help treat inflammatory pain without the side effects associated with opioids and COX-2 inhibitors. 1 The findings could open up a new indication for Resolvyx Pharmaceuticals...
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