BC Innovations | Jun 4, 2019
Distillery Therapeutics

RELMα and RETN for Gram-positive and Gram-negative bacterial infections

DISEASE CATEGORY: Infectious disease INDICATION: Gram-positive bacterial infection; Gram-negative bacterial infection; Pseudomonas; Streptococcus Bacterial culture studies suggest RELMα and RETN could help treat Gram-positive and other bacterial infections. In cultures of Gram-positive Streptococcus pyogenes and...
BC Innovations | Jan 4, 2018
Translation in Brief

New Therapeutic Targets and Biomarkers: December 2017

New Therapeutic Targets and Biomarkers: December 2017 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database during December 2017. Therapeutic targets are defined as any protein, gene or other...
BC Innovations | Dec 19, 2017
Distillery Therapeutics

Infectious disease

INDICATION: Sepsis Mouse and cell culture studies suggest RETN or an RETN-derived peptide could help treat sepsis. In a mouse model of lipopolysaccharide (LPS)-induced septic shock, transgenic expression of human RETN increased survival and decreased...
BioCentury | Dec 5, 2011
Product Development

Change-up for BATTER-UP

A year after starting a biomarker study in rheumatoid arthritis, a broad-based consortium has been forced to retool its recruitment strategy. The Biomarkers of Anti-TNF Treatment Efficacy in Rheumatoid Arthritis -Unresponsive Populations Consortium had hoped...
BC Innovations | Aug 6, 2009
Targets & Mechanisms

Signaling insulin resistance in obesity

Researchers at Monash University have made a case for PEDF as a missing link between obesity and insulin resistance that leads to diabetes. 1 However, the adipose-secreted cytokine has many biological roles, which could make...
BC Innovations | Apr 30, 2009
Distillery Therapeutics

Indication: Inflammation

This week in therapeutics Indication Target/marker/ pathway Summary Licensing status Publication and contact information Inflammation Inflammation Resistin-like-α (HIMF; Retnla) In vitro and mouse studies suggest that upregulating Retnla expression on macrophages could help treat inflammation....
BC Innovations | Feb 19, 2009
Targets & Mechanisms

Resistin becomes less futile

University of Pennsylvania researchers have removed a roadblock to studying the role of resistin in diabetes by developing a mouse model that has human-like expression of the target. Although the model may become a tool...
BC Innovations | Feb 12, 2009
Distillery Techniques

Technology: Disease models

This week in techniques Approach Summary Licensing status Publication and contact information Disease models Mouse model of human resistin expression A mouse model expressing macrophage-derived human resistin may help guide the development of compounds to...
BC Week In Review | Jan 22, 2001
Company News

University of Pennsylvania other research news

University researchers published in Nature research that helps explain the link between Type II diabetes and obesity. They reported that the peptide hormone resistin causes tissue resistance to insulin, as evidenced by improvement of insulin...
BioCentury | Jan 22, 2001
Tools & Techniques

A new target for diabetes

Obesity and Type 2 diabetes are strongly associated, but the biochemical basis had not been identified. A protein called resistin that is secreted by fat cells may be that link. New work by University of...
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