BC Extra | Feb 9, 2013
Politics & Policy

NCATS seeking partners for Gaucher's, heart failure compounds

NIH's National Center for Advancing Translational Science (NCATS) is seeking Cooperative Research and Development Agreement partners to "collaborate in the final stages of lead optimization, in vitro and in vivo evaluation and preclinical development" of...
BioCentury | Mar 15, 2010
Regulation

IPF pipeline

IPF pipeline Company Product Description Status [primary endpt] InterMune Inc. (NASDAQ:ITMN)/ Shionogi & Co. Ltd. (Tokyo:4507; Osaka:4507) Esbriet pirfenidone (Pirespa-Japan) Small molecule inhibitor of pro-inflammatory cytokines such as TNF alpha and IL-1 beta and pro-fibrotic...
BC Week In Review | Mar 23, 2009
Clinical News

Compugen preclinical data

In a mouse model of pulmonary fibrosis, CGEN-25009 reduced fibrosis to levels comparable to healthy mice as measured by histology staining and pressure at the airway opening. CGEN-25009 is a peptide that activates relaxin-insulin-like family...
BioCentury | Mar 5, 2007
Tools & Techniques

Predicting active peptides

Compugen Ltd. says it has developed an in silico discovery engine for peptides that bind GPCRs. So far, the engine has yielded eight peptides with dose-dependent activity, and CGEN plans to advance two into preclinical...
BC Week In Review | Jan 28, 2002
Company News

Stanford University School of Medicine other research news

Researchers published in Science the identification of the GPCRs LGR7 and LGR8 as the receptors for relaxin , a peptide involved in the remodeling of reproductive tissues during pregnancy, as well as lung and skin remodeling,...
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