BC Innovations | Dec 15, 2017
Tools & Techniques

Caveat fermentor

Four papers published this quarter have called out caveats in translational microbiome research, and proposed solutions to improve experimental design in the field. The papers identified hurdles in characterizing microbiome-phenotype relationships, quantifying microbiotic load, choosing...
BC Innovations | Feb 25, 2016
Distillery Therapeutics

Therapeutics: Regenerating islet-derived 3γ (REG3G)

Hepatic disease INDICATION: Liver disease Mouse studies suggest promoting REG3G expression could help treat alcoholic hepatitis. In a mouse model of alcohol dependency, transgenic expression of human REG3G in the intestinal epithelium decreased liver inflammation...
BC Innovations | Sep 3, 2015
Distillery Techniques

Techniques: Markers for differential diagnosis of mucinous and non-mucinous pancreatic cysts

Biomarkers TECHNOLOGY: Proteomics Four proteins - afamin (AFM) , lipocalin ( NGAL ; LCN2 ), polymeric immunoglobulin receptor (PIGR) and regenerating islet-derived 1 α ( REG1A ) - could help differentially diagnose mucinous and non-mucinous pancreatic cysts. Mass spectrometry-based proteomic screening...
BC Innovations | Sep 3, 2015
Tools & Techniques

Sequencing in Rare Form

Single-cell RNA sequencing captures rich sets of functional information from common and rare cell types alike, but most analytical techniques can't distinguish rare signals from noise. A group from the Netherlands has published a method...
BC Innovations | Aug 29, 2013
Distillery Therapeutics

Indication: Cancer

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Pancreatic cancer Regenerating islet-derived 3b (REG3B) Mouse studies suggest inhibiting REG3B could help treat pancreatic cancer. REG3B expression has previously been...
BC Innovations | Sep 11, 2008
Distillery Therapeutics

This Week in Therapeutics

This week in therapeutics Indication Target/marker/ pathway Summary Licensing status Publication and contact information Infectious disease Enterococcus Regenerating islet-derived 3g (REG3G); toll-like receptor 4 (TLR4) A study in mice suggests that oral TLR4 agonists could...
BC Innovations | Jul 10, 2008
Distillery Therapeutics

This Week in Therapeutics

This week in therapeutics Indication Target/marker/ pathway Summary Licensing status Publication and contact information Cancer Pancreatic cancer Lipocalin 2 (LCN2); regenerating islet-derived 1a (REG1A); regenerating islet-derived 3a (REG3A); TIMP metallopeptidase inhibitor 1 (TIMP1); insulin-like growth...
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