BC Innovations | Jul 24, 2018
Distillery Techniques

Assays and screens

TECHNOLOGY: Binding assays; cellular assays A screening method using non-coding SNPs from genome-wide association studies (GWAS) could help identify new drug targets. The method involves five steps: creating double-stranded 31-base pair DNA constructs with each...
BC Innovations | Dec 8, 2017
Targets & Mechanisms

Pathways emerging from ASH

A survey of the emerging molecular targets at this year’s American Society of Hematology conference indicates that while harnessing the immune system to treat cancer remains a dominant interest, processes for tuning protein levels --...
BC Innovations | Aug 4, 2016
Distillery Therapeutics

Therapeutics: Recombination signal binding protein for immunoglobulin κ J region (RBPJ; CBF1)

Cardiovascular disease INDICATION: Myocardial infarction (MI) Mouse studies suggest inhibiting RBPJ could help treat MI. In a mouse model of MI, cardiomyocyte-specific knockout of RBPJ increased cardiac function and decreased morphological defects and fibrotic scar...
BC Innovations | Oct 28, 2010
Distillery Therapeutics

Indication: Renal disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Renal disease Renal damage; end-stage renal disease (ESRD) Notch homolog 1 translocation-associated (NOTCH1); recombination signal binding protein for immunoglobulin k-J region (RBPJ; CBF1) Studies in mice...
BC Innovations | Apr 2, 2009
Distillery Therapeutics

Indication: Cancer

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Acute megakaryoblastic leukemia (AMKL) One twenty-two protein (RBM15; OTT); megakaryocytic acute leukemia (MKL1; MAL); myeloproliferative leukemia virus oncogene (MPL); recombination signal...
BC Week In Review | Apr 19, 1999
Clinical News

Mendel regulatory update

U.S. Patent No. 5,891,859 issued to Michigan State University covering a method of regulating the expression of cold and dehydration-regulated genes in a plant by transforming the plant with the CBF1 transcription factor. Mendel has...
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