BC Innovations | Jul 10, 2019
Distillery Therapeutics

Activating RIPK3 could help treat melanoma and lung cancer

DISEASE CATEGORY: Cancer INDICATION: Melanoma; lung cancer Activating RIPK3 could help treat melanoma and lung cancer. Among 228 skin cutaneous melanoma patients, high RIPK3 transcript levels were associated with longer survival. Intratumoral injection of matched...
BC Innovations | Aug 31, 2017
Targets & Mechanisms

Necroptosis strikes again

Adding to the list of necroptosis-related pathologies, a group from Arizona State University has shown the cell death pathway is activated in Alzheimer’s disease. The data, published last month in Nature Neuroscience , identify potential targets...
BC Innovations | Dec 22, 2016
Targets & Mechanisms

Opportunity Knocks

Despite its continued emphasis on tapping external innovation for new opportunities, industry is still leaving on the table scores of unexploited drug targets identified at universities, according to an analysis of BioCentury’s BCIQ: BioCentury Online...
BC Innovations | Aug 4, 2016
Distillery Therapeutics

Therapeutics: Tumor necrosis factor receptor superfamily member 21 (TNFRSF21; DR6); receptor-interacting serine-threonine kinase 1 (RIPK1; RIP1); RIPK3 (RIP3)

Cancer INDICATION: Cancer; breast cancer; lung cancer; melanoma Cell culture and mouse studies suggest inhibiting the necroptosis-related proteins RIPK1 , RIPK3 or TNFRSF21 could help treat metastatic breast, lung, melanoma and other metastatic cancers. In co-cultures...
BC Innovations | Aug 4, 2016
Distillery Therapeutics

Therapeutics: Receptor-interacting serine-threonine kinase 1 (RIPK1; RIP1); RIPK3 (RIP3); mixed-lineage kinase domain-like (MLKL)

Cardiovascular disease INDICATION: Atherosclerosis Patient sample and mouse studies suggest inhibiting the necroptosis-related proteins RIPK1 , RIPK3 or MLKL could help treat atherosclerosis. Levels of RIPK3 and MLKL were higher in carotid plaque samples from atherosclerosis...
BC Innovations | May 12, 2016
Distillery Therapeutics

Therapeutics: Receptor-interacting serine-threonine kinase 3 (RIPK3; RIP3); tumor necrosis factor receptor 1 (TNFRSF1A; TNFR1; CD120a); HECT domain and ankyrin

Cancer INDICATION: Colorectal cancer; cancer Mouse studies suggest inhibiting TNFRSF1A or RIPK3 could help treat colon and other cancers harboring loss-of-function HACE1 mutations. In a mouse model of HACE1-mutant colon cancer, systemic knockout of TNFRSF1A...
BC Innovations | Apr 28, 2016
Distillery Therapeutics

Therapeutics: Fas-associated via death domain (FADD); receptor-interacting serine-threonine kinase 3 (RIPK3; RIP3)

Cancer INDICATION: Colorectal cancer Mouse studies suggest necroptotic cancer cells could help treat colon cancer. In a mouse colon carcinoma cell line, vector-mediated expression of FADD and RIPK3 increased necroptosis compared with no treatment. In...
BC Innovations | Apr 14, 2016
Distillery Therapeutics

Therapeutics: Receptor-interacting serine-threonine kinase 3 (RIPK3; RIP3)

Cancer INDICATION: Pancreatic cancer Patient sample and mouse studies suggest inhibiting RIPK3 could help treat pancreatic ductal adenocarcinoma (PDAC). In patient samples, levels of RIPK3 were higher in PDAC tumors than in the surrounding normal...
BC Innovations | Mar 3, 2016
Distillery Therapeutics

Therapeutics: Receptor-interacting serine-threonine kinase 3 (RIPK3; RIP3); mixed-lineage kinase domain-like (MLKL)

Renal disease INDICATION: Renal damage Cell and mouse studies suggest inhibiting RIPK3 or MLKL could help treat crystal-induced acute kidney injury (AKI). In mouse kidney epithelial cells, siRNA targeting RIPK3 or MLKL decreased cell death...
BC Innovations | Jan 21, 2016
Distillery Therapeutics

Therapeutics: Receptor-interacting serine-threonine kinase 3 (RIPK3; RIP3); calcium calmodulin-dependent protein kinase II (CAMK2)

Cardiovascular disease INDICATION: Heart failure Cell culture and mouse studies suggest inhibiting RIPK3 or CAMK2 could help treat heart failure. Levels of RIPK3 and RIPK3-phosphorylated CAMK2 were higher in rat ventricular myocytes under hypoxic conditions...
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