BioCentury | Jun 12, 2020
Product Development

June 11 Quick Takes: Sobi licenses Selecta gout therapy; plus Viela’s first approval, CSL, BMS, Sirnaomics’ spinout, Denali-Sanofi

...death 1 PD-L1 (B7-H1; CD274) - Programmed cell death 1 ligand 1 RIPK1 (RIP1) - Receptor-interacting serine-threonine kinase...
...Inc. CD19 Programmed cell death 1 (PD-1) (PDCD1) (CD279) Programmed cell death 1 ligand 1 (PD-L1) (B7-H1) (CD274) Factor XIIa Receptor-interacting serine-threonine kinase...
BioCentury | May 1, 2020
Distillery Therapeutics

Blocking necroptosis to treat inflammatory bowel disease

...the integrity of the intestinal epithelium. A RIPK3 inhibitor tool compound also extended survival. TARGET/MARKER/PATHWAY: Receptor-interacting serine-threonine kinase...
...CONTACT: Wei Mo, same affiliation as above email: wmo@xmu.edu.cn Claire Quang Xiamen University SET domain bifurcated 1 (SETDB1) (KMT1E) Receptor-interacting serine-threonine kinase...
BioCentury | Mar 25, 2020
Product Development

Repurposing candidates for COVID-19 from UCSF, Aldeyra

...containing 2 BRD4 - Bromodomain containing 4 PTGES2 - Prostaglandin E synthase-2 RIPK1 (RIP1) - Receptor-interacting serine-threonine kinase...
BioCentury | Feb 25, 2020
Distillery Therapeutics

Inhibiting necroptosis to treat ischemic stroke

...lateral sclerosis (ALS). TARGET/MARKER/PATHWAY: Acid-sensing ion channel-1A (ASIC1A); N-ethylmaleimide sensitive factor, vesicle fusing ATPase (NSF); receptor-interacting serine-threonine kinase...
...Science Center, Houston, Texas email: michael.x.zhu@uth.tmc.edu Claire Quang Shanghai Jiao Tong University School of Medicine Acid-sensing ion channel-1A (ASIC1A) Receptor-interacting serine-threonine kinase...
BioCentury | Feb 5, 2020
Product Development

Leaner GSK ups R&D investments in immunology, genetics

...HIF-PH (EGLN) - Hypoxia-inducible factor prolyl hydroxylase RIPK1 (RIP1) - Receptor-interacting serine-threonine kinase 1 RIPK2 (RICK) - Receptor-interacting serine-threonine kinase...
BioCentury | Sep 13, 2019
Tools & Techniques

Getting higher-quality hits out of DNA-encoded libraries

...tyrosine kinase Cbl-b - Casitas B cell lymphoma-b ENPP2 (ATX) - Autotaxin RIPK1 (RIP1) - Receptor-interacting serine-threonine kinase...
...Inc. Roche Pfizer Inc. The Scripps Research Institute University of California Irvine X-Chem Inc. Bruton's tyrosine kinase (Btk) Casitas B cell lymphoma-b (Cbl-b) Receptor-interacting serine-threonine kinase...
BioCentury | Aug 5, 2019
Clinical News

Aug. 5 Clinical Quick Takes: Emgality meets for migraine with treatment failures; plus Verona, Alkahest-Grifols, Squarex and Denali-Sanofi

...Targets: CGRP - Calcitonin gene-related peptide; PDE-3 - Phosphodiesterase-3; PDE-4 - Phosphodiesterase-4; RIPK1 (RIP1) - Receptor-interacting serine-threonine kinase...
...VRP554) SQX770 Alkahest Inc. Denali Therapeutics Inc. Eli Lilly and Co. Grifols S.A. Sanofi Squarex LLC Verona Pharma plc Calcitonin gene-related peptide (CGRP) Phosphodiesterase-3 (PDE-3) Phosphodiesterase-4 (PDE-4) Receptor-interacting serine-threonine kinase...
BioCentury | Jul 10, 2019
Distillery Therapeutics

Activating RIPK3 could help treat melanoma and lung cancer

...steps by Walking Fish Therapeutics Inc. include further mechanistic studies to support clinical development. TARGET/MARKER/PATHWAY: Receptor-interacting serine-threonine kinase...
...21, 2019 doi:10.1126/sciimmunol.aaw2004 CONTACT: Andrew Oberst, University of Washington, Seattle, Wash. email: oberst@uw.edu Claire Quang University of Washington Receptor-interacting serine-threonine kinase...
BioCentury | Apr 19, 2019
Targets & Mechanisms

The next wave in neurodegeneration expands beyond neurons

...in B cells 1 (NF-kB; NFKB1; p105; p50) ImStar Therapeutics Inc. IMS-088 ALS, FTD Preclin Receptor-interacting serine-threonine kinase...
...CIAS1) - NLR family pyrin domain containing 3 PGRN (PCDGF) - Progranulin RIPK1 (RIP1) - Receptor-interacting serine-threonine kinase...
...in B cells 1 (NF-kB) (NFKB1) (p105) (p50) Phosphodiesterase-4 (PDE-4) Progranulin (PGRN) (PCDGF) Receptor for advanced glycation endproducts (RAGE) Receptor-interacting serine-threonine kinase...
BioCentury | Apr 11, 2019
Targets & Mechanisms

A venture view of biological white space

...CIAS1) - NLR family pyrin domain containing 3 PGRN (PCDGF) - Progranulin RIPK1 (RIP1) - Receptor-interacting serine-threonine kinase...
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