...In vitro , cell culture and mouse studies identified a SALL4-derived peptide inhibitor of the SALL4-RBBP4...
...as adjuvant therapy for high-risk HCC. TARGET/MARKER/PATHWAY: Spalt like transcription factor 4 (SALL4); retinoblastoma binding protein 4 (RBBP4; RBAP48...
...of Singapore, Singapore email: daniel.tenen@nus.edu.sg Claire Quang Brigham and Women's Hospital Harvard Medical School National University of Singapore Retinoblastoma binding protein 4 (RBBP4) (RBAP48) Spalt...

...consists of five subunits: the three core enzyme-related proteins, EED , EZH2 and SUZ12 ; RBBP4...
...and AT-Rich interaction domain containing 2; PRC2 - polycomb repressive complex 2; RBBP4 (RBAP48) - Retinoblastoma binding protein 4...

...information Neurology Cognitive dysfunction Retinoblastoma binding protein 4 (RBBP4; RBAP48) Studies in patient samples and mice suggest increasing RBAP48...
...tissue samples showed that RBAP48 levels decreased with age. In young transgenic mice, inhibition of Rbap48...
...in the dentate gyrus impaired performance on memory tasks. In aged mice, lentiviral expression of Rbap48...

...information Autoimmune disease Sjögren's syndrome Retinoblastoma binding protein 4 (RBBP4; RBAP48) A study in mice suggests that inhibiting RBAP48...
...autoimmune disease of the salivary and lacrimal glands. In adult mice, selective overexpression of human RBAP48...
...saliva than that seen in wild-type mice. Next steps include evaluating the preventative effects of RBAP48-targeting...