BioCentury | Aug 14, 2019
Distillery Therapeutics

RASGRF2-MEK inhibition for cocaine addiction

DISEASE CATEGORY: Neurology INDICATION: Addiction Blocking phosphorylation of MAPK1 and MAPK3 in the nucleus accumbens region of the brain by inhibiting RASGRF2-MEK signaling could treat cocaine addiction. In a mouse model of the addiction, the...
BioCentury | Dec 9, 2010
Distillery Therapeutics

Indication: Neurology

...Neurology Parkinson's disease (PD) Ras protein-specific guanine nucleotide-releasing factor 1 (RASGRF1) Studies in nonhuman primates and mice suggest that inhibiting RASGRF1...
...dyskinesia side effects in PD. In a mouse model of PD, compared with wild-type controls, Rasgrf1...
...the efficacy of l-dopa. In a nonhuman primate model of PD, gene therapy-mediated inhibition of RASGRF1...
Items per page:
1 - 2 of 2