BioCentury | May 28, 2020
Distillery Therapeutics

Increasing WWTR1 degradation for NASH

...NASH. The cholesterol trafficking proteins GRAMD1B and GRAMD1C activate SAC, which in turn triggers a RHOA-mediated...
...1 (WWTR1; TAZ); GRAM domain containing 1B (GRAMD1B); GRAMD1C; soluble adenylyl cyclase (SAC; ADCY10); Ras homolog gene family member A (RHOA...
...email: iat1@columbia.edu Claire Quang Columbia University WW domain containing transcription regulator 1 (WWTR1) (TAZ) Soluble adenylyl cyclase (SAC) (ADCY10) Ras homolog gene family member A (RHOA...
BioCentury | Apr 5, 2019
Targets & Mechanisms

Breaking up Hippo to tame proliferation

...in the Hippo pathway components linked to cancer include: NF2 in mesothelioma, schwannoma and meningioma; RHOA...
...Large tumor suppressor homolog 1; LATS2 - Large tumor suppressor homolog 2; RHOA - Ras homolog gene family member A...
BioCentury | Apr 13, 2018
Targets & Mechanisms

Hello RNA

...GTPase-GDP dissociation stimulator 1 (RAP1GDS1) NSCLC Cell-based Inhibiting the synthetically lethal pair RAP1GDS1 and ras homolog gene family member A (RHOA...
BioCentury | Apr 13, 2018
Targets & Mechanisms

Meeting the burden

...DDR CYP3A5 PARP Castration-resistant prostate cancer (CRPC) 5900 Topoisomerase Proliferation regulation Proliferation regulation RAP1GDS1; KRAS RHOA...
BioCentury | Sep 14, 2017
Targets & Mechanisms

Platelets YAP at cancer

...S1P receptor, on detached, metastasizing cancer cells (orange) to activate the intracellular G-protein RHOA . RHOA...
...cancer cells, and RHOA activation was required for YAP1 dephosphorylation and platelet-enhanced cancer cell survival. RHOA...
...1 regulatory subunit 12A PPP1CC - Protein phosphatase 1 catalytic subunit γ isoform RHOA - Ras homolog gene family member A...
BioCentury | Oct 27, 2016
Distillery Therapeutics

Cancer

...INDICATION: Prostate cancer Cell culture studies identified an inhibitor of the AKAP13 - RHOA interaction that...
...Next steps could include testing the compound in animal models of prostate cancer. TARGET/MARKER/PATHWAY: Ras homolog gene family member A (RHOA...
...University of Modena and Reggio Emilia, Modena, Italy email: fanelli@unimo.it Steven Hochhauser A-kinase anchoring protein 13 (AKAP13) Ras homolog gene family member A (RHOA...
BioCentury | Sep 26, 2016
Company News

Institut National de la Sante et de la Recherche Medicale, Evotec deal

Evotec partnered with INSERM’s Inserm Transfert subsidiary to characterize and develop selective modulators of Ras homolog gene family member B (RHOB) to treat cancer. The partners did not respond to inquiries. The project is the...
BioCentury | Oct 9, 2014
Targets & Mechanisms

Ral-lying around Ras

...RalA and RalB activity was significantly decreased in inhibitor-treated animals, whereas the related GTPase Ras homolog gene family member A (RHOA...
BioCentury | Aug 21, 2014
Distillery Techniques

Technology: Markers

...DNA hypermethylation, microsatellite unstable tumors with high mutation rates, genomically stable tumors with frequent ras homolog gene family member A (RHOA...
BioCentury | Feb 6, 2014
Distillery Therapeutics

Indication: Pulmonary disease

...Ras homolog family member A (RHOA) Cell culture and mouse studies suggest blocking nitration of RHOA...
...mouse model of ALI, injection of a RHOA-derived peptide containing Tyr34 prior to injury blocked Rhoa...
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