BioCentury | Aug 16, 2017
Distillery Techniques

Biomarkers

TECHNOLOGY: Tissue markers Tumor levels of a panel of mRNA splice variants could help diagnose prostate cancer in African-Americans and levels of one PI3KCD variant could help predict survival. Transcriptomic analysis of tumor samples from...
BioCentury | May 23, 2017
Distillery Therapeutics

Cancer

INDICATION: Melanoma Cell culture studies suggest inhibiting PRKCD , PKCE or RASGRP3 could help treat GNAQ -mutant uveal melanoma. Levels of RASGRP3 were higher in five human GNAQ-mutant uveal melanoma cell lines than in four human...
BioCentury | Sep 17, 2009
Distillery Therapeutics

Indication: Cancer

...RASGRP1); RASGRP4 A study in mice suggests that agonizing p38 MAPK or antagonizing RASGRP1 and RASGRP4...
...to MEK inhibitors. In mice, MEK inhibitor-resistant leukemia cells had higher expression of RASGRP1 and RASGRP4...
BioCentury | Feb 5, 2009
Distillery Therapeutics

Indication: Neurology

This week in therapeutics Indication Target/ marker/ pathway Summary Licensing status Publication and contact information Neurology Parkinson's disease (PD) Calcium and DAG-regulated guanine nucleotide exchange factor 1 (RASGRP1; CALDAG-GEFI); Calcium and DAG-regulated guanine nucleotide exchange...
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