BioCentury | Oct 31, 2017
Distillery Techniques

Biomarkers

TECHNOLOGY: SNPs SNPs on 30 genomic loci could help predict the risk of schizophrenia. Genome-wide association studies in 47,559 schizophrenia patients and 70,936 healthy volunteers identified associations between the disease and SNPs on 30 loci,...
BioCentury | Mar 26, 2012
Emerging Company Profile

BioMetrx: RASS restoration

BioMetrx LLC has early data for its Rasstore suggesting that restoring levels of the tumor suppressor gene RASSF1A may lead to superior safety and efficacy compared to current prostate cancer therapies. Rasstore selectively inhibits an...
BioCentury | Jan 30, 2012
Company News

BioMetrx, Georgetown University deal

Georgetown University Medical Center granted newco BioMetrx exclusive, worldwide rights to cancer product Rasstore. Rasstore is a fluorescent carbazole analog of mahanine, which increases mRNA expression of the tumor suppressor gene Ras association domain family...
BioCentury | Jan 25, 2012
Company News

Newco BioMetrx licenses RASSF1A product

Georgetown University Medical Center granted newco BioMetrx LLC (Bethesda, Md.) exclusive, worldwide rights to cancer product Rasstore. Rasstore is a fluorescent carbazole analog of mahanine, which increases mRNA expression of the tumor suppressor gene Ras...
BioCentury | Nov 21, 2011
Clinical News

ConfirmMDx for Lung Cancer diagnostic data

Data from sputum samples from 40 NSCLC patients and 52 symptomatic, cancer-free controls showed that using methylation specific PCR to screen for the methylated Ras association domain family 1A (RASSF1A) gene produced 60% sensitivity and...
BioCentury | Mar 18, 2010
Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer Ras associated domain family 1A (RASSF1A) In vitro and mouse studies identified a fluorescent carbazole analog of mahanine that could help treat cancer. In...
BioCentury | Aug 27, 2009
Distillery Therapeutics

Indication: Cancer

...cancer; gastric cancer Ras association domain family member 2 (RASSF2); secreted frizzled-related protein 2 (SFRP2) Studies of patient samples suggest that RASSF2...
...In primary colorectal and gastric cancer tissue samples, methylation of the promoter regions of the RASSF2...
BioCentury | Jul 9, 2007
Clinical News

Lung cancer biomarker cancer data

In 100 patients with NSCLC or non-cancerous lung disease, ECX's undisclosed biomarker had a 69% sensitivity and a 91% specificity in identifying patients with NSCLC. ECX said its biomarker was significantly better at detecting NSCLC...
BioCentury | May 23, 2005
Clinical News

MethylGene, MGI preclinical data

MG98 sensitized and overcame the resistance of human renal cancer cells to the effects of interferon (IFN) alpha. The DNA methyltransferase 1 inhibitor enhanced the effect of IFN alpha by demethylation and reactivation of the...
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