BC Innovations | Sep 15, 2011
Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer Colony-stimulating factor 1 receptor (CSF1R; C-FMS; CD115); inhibitor of k light polypeptide gene enhancer in B cells kinase-b (IKBKB; IKK2); rap guanine nucleotide exchange...
BC Innovations | Aug 20, 2009
Targets & Mechanisms

New mechanism for sulfonylureas

Japanese researchers have uncovered a second mechanism by which sulfonylureas stimulate insulin production. 1 Exploiting the new mechanism to develop sulfonylurea analogs could produce compounds that do not exhaust the insulin-producing capacity of pancreatic β...
BC Innovations | Aug 6, 2009
Distillery Therapeutics

Indication: Endocrine disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Endocrine disease Diabetes Rap guanine nucleotide exchange factor 4 (RAPGEF4; EPAC2); RAP1 GTPase activating protein (RAPGAP; RAP1) Studies in mice identified EPAC2 as the intracellular target...
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