BioCentury | Jul 31, 2020
Distillery Therapeutics

Vesicular trafficking protein fusion targets for metastatic osteosarcoma

...peptide based on one of the RAB22A fusions reduced lung metastases and extended survival. TARGET/MARKER/PATHWAY: Rap1 GTPase-GDP dissociation stimulator 1 (RAP1GDS1)...
...above email: kangtb@sysucc.org.cn CONTACT: Jian Chen, Soochow University, Suzhou, China email: chenjian@cibr.ac.cn Claire Quang Sun Yat-sen University Soochow University Rap1 GTPase-GDP dissociation stimulator 1 (RAP1GDS1) RAB22A...
BioCentury | Feb 28, 2020
Distillery Therapeutics

Manipulating RAP1GDS1 splicing for breast and lung cancers

...lowers the 607:558 ratio. In mice with breast cancer, the oligo reduced tumor burden. TARGET/MARKER/PATHWAY: Rap1 GTPase-GDP dissociation stimulator 1 (RAP1GDS1)...
BioCentury | Apr 13, 2018
Targets & Mechanisms

Hello RNA

...mouse Inhibiting RAB27A could help treat melanoma by decreasing invasion and motility. Centenary Institute 5167 Rap1 GTPase-GDP dissociation stimulator 1 (RAP1GDS1)...
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