...the disease, systemic knockout of RAG2 or IL-6 decreased GI polyp size compared with normal RAG2...
...chimeric mAb against IL-6, to treat cancer. TARGET/MARKER/PATHWAY: Janus kinase-1 (JAK-1); JAK-2; interleukin-6 (IL-6); recombination activating gene 2 (RAG2...
...Jones, McGill University, Montreal, Quebec email: russell.jones@mcgill.ca; russell.jones@vai.org Sandi Wong McGill University Interleukin-6 (IL-6) Janus kinase-1 (JAK-1) Janus kinase-2 (JAK-2) Recombination activating gene 2 (RAG2) Gastrointestinal...

...form of severe combined immunodeficiency associated with mutations in recombination activating genes (RAGs). In a RAG2-mutant...
...in other diseases associated with chronic inflammation of the small intestine and colon. TARGET/MARKER/PATHWAY: Recombination activating gene 2 (RAG2...

...Disease models Recombination activating gene 2 (RAG2) knockout pigs to model immunodeficiency and evaluate transplant-based therapies Pigs with RAG2...
...transplant-based therapies. In vitro, engineered transcription activator-like effector nucleases (TALENs) were used to knock out RAG2...
...used in a somatic cell nuclear transfer procedure to generate eight RAG2 knockout pigs. The RAG2...

...that target the liver stage of human malarial strain Plasmodium falciparum. In the mice, recombination activating gene 2 (Rag2...