21:48 , Jun 6, 2019 |  BC Innovations  |  Translation in Brief

CRISPR pioneer Zhang describes new technique to insert genes

Feng Zhang's latest study brings the gene editing field one step closer to correcting and replacing, rather than just disrupting, target genes. The challenge now will be translating the technique from prokaryotic cells to eukaryotic...
23:35 , Jun 4, 2019 |  BC Extra  |  Tools & Techniques

OHSU's Mitalipov proposes path forward for germline gene editing

Germline gene editing pioneer Shoukhrat Mitalipov has weighed in on therapeutic use of the technology, writing in a Nature Medicine perspective that it should only be applied when it can convert a mutated gene to...
21:58 , May 28, 2019 |  BC Innovations  |  Translation in Brief

Liu’s new strategy could make gene editing insertions more precise

The latest study from CRISPR veteran David Liu describes a new tweak to the gene editing machinery that could better position it to correct, rather than just disrupt, gene targets. Using CRISPR to disrupt a...
17:29 , Apr 22, 2019 |  BC Innovations  |  Distillery Therapeutics

STAG2 identified as target in glioblastoma and Ewing sarcoma

DISEASE CATEGORY: Cancer INDICATION: Brain cancer; sarcoma Cell culture studies suggest inhibiting STAG2 could sensitize glioblastoma and Ewing sarcoma to agents that disrupt repair of DNA double-strand (dsDNA) breaks. In two human glioblastoma and one...
13:30 , Dec 5, 2018 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Brain cancer Cell studies suggest PARP inhibitors and other inhibitors of DNA damage repair could help treat brain cancers that have complex genome rearrangements (chromothripsis). In mouse medulloblastoma cells with homozygous XRCC4 deletion-induced chromothripsis,...
04:50 , Nov 30, 2018 |  BC Innovations  |  Targets & Mechanisms

Revving up metabolism at ASH 2018

Cancer metabolism is a prominent theme at this year’s ASH meeting, with researchers broadening the tent from metabolic targets that drive hematologic malignancies to those that intersect with other hot topics, notably immuno-oncology and epigenetics....
20:16 , Nov 29, 2018 |  BC Innovations  |  Translation in Brief

Beyond BRCA

Researchers at the German Cancer Research Center have identified synthetic lethal markers beyond BRCA that expand the pool of patients who may benefit from PARP inhibitors and other compounds targeting DNA damage repair pathways. In...
21:15 , Jul 31, 2018 |  BC Innovations  |  Translation in Brief

Satellite damage

Researchers at the Salk Institute for Biological Studies have figured out how RNA transcribed from satellite DNA repeats could promote tumorigenesis by hindering DNA repair, highlighting a potential new target for cancer. Satellite RNAs are...
21:15 , Apr 17, 2018 |  BC Innovations  |  Distillery Techniques

Biomarkers

TECHNOLOGY: Gene profiling; tissue markers A panel of 40 DNA damage repair signatures in tumors could help predict survival in eight types of cancer. The 40 signatures, including homologous recombination and loss-of-heterozygosity signatures, are calculated...
03:45 , Apr 13, 2018 |  BC Innovations  |  Targets & Mechanisms

Meeting the burden

A major theme at this year’s AACR is the abundance of preclinical discovery driven by molecular signatures in patient samples, suggesting the research community is heeding the call for studies better grounded in human data,...