BioCentury | Dec 1, 2020
Product Development

With new Phase III results in rare anemia, Agios moves toward first non-oncology submission

...ACTIVATE study, mitapivat significantly increased hemoglobin levels vs. placebo in patients with a rare anemia, pyruvate kinase...
...to $46.54 on Tuesday.TARGETSPKLR - Pyruvate kinase liver and RBCPKR - Pyruvate kinase isoenzyme Paul Bonanos mitapivat (AG-348) Agios Pharmaceuticals Inc. PK deficiency pyruvate kinase...
BioCentury | Nov 21, 2020
Product Development

How Forma is working to show the sickle cell community it’s in for the long haul

...rapid COVID-19 testing and additional PPE.TARGETSPKR – Pyruvate kinase...
BioCentury | Nov 14, 2020
Product Development

ASH 2020 snapshot: efficacy data in hot emerging areas

...SIGLEC2)CD3z (CD247) – CD3zeta p53 (TP53)PKR - Pyruvate kinase...
...BCMA) (TNFRSF17) (CD269) B cell CLL lymphoma 11A (BCL11A) Hemoglobin Pyruvate kinase...
BioCentury | Nov 13, 2020
Product Development

Next-generation sickle cell readouts at ASH: Data Byte

...I studies of their PKR allosteric activators, which improves the metabolic health of RBCs.TARGETSPKR - Pyruvate kinase...
...Tuzman bluebird bio Inc. CRISPR Therapeutics AG Aruvant Sciences Inc. Forma Therapeutics Inc. Agios Pharmaceuticals Inc. B cell CLL lymphoma 11A (BCL11A) Hemoglobin Pyruvate kinase...
BioCentury | Jun 13, 2020
Product Development

Additional durability data build confidence for gene editing, gene therapies in hemoglobinopathies

...and increased hemoglobin expression. Editas gained $1.98 to $26.99 on the data. Targets PKR - Pyruvate kinase...
BioCentury | Dec 20, 2019
Financial News

Forma’s $100M series D cements pivot from discovery shop to heme and cancer therapeutics

...IDH1 - Isocitrate dehydrogenase 1 (IDH1); p300 (EP300) - E1A binding protein p300; PKR - Pyruvate kinase...
BioCentury | May 3, 2019
Product Development

Independents’ day: after their first solo launch, biotechs look to new partnering strategies

...Aminolevulinate synthase-1 IDH1 - Isocitrate dehydrogenase 1 IDH2 - Isocitrate dehydrogenase 2 PKR - Pyruvate kinase...
BioCentury | Jan 3, 2019
Distillery Therapeutics

Renal

...or PKM2 inhibitors in in AKI models. TARGET/MARKER/PATHWAY: Aldo-keto reductase family 1 member A1 (AKR1A1); pyruvate kinase...
...Reserve University, Cleveland, Ohio email: jonathan.stamler@case.edu Chris Lieu Case Western Reserve University Aldo-keto reductase family 1 member A1 (AKR1A1) Pyruvate kinase...
BioCentury | Nov 30, 2018
Targets & Mechanisms

Adhesion targets emerge at ASH 2018

...disorder hereditary xerocytosis. Using next-generation sequencing (NGS), another study found PIEZO1 mutations in patients with pyruvate kinase...
BioCentury | Sep 29, 2017
Strategy

Agios’ acceleration

...a patent application from Beth Israel Deaconess Medical Center covering a platform used to identify pyruvate kinase...
...advanced clinical compound among these programs is AG-348 , an oral small molecule activator of pyruvate kinase...
...to treat adults with pyruvate kinase deficiency. The inherited disorder is caused by mutations in the pyruvate kinase...
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