BioCentury | May 28, 2020
Distillery Therapeutics

Reducing kidney damage in lupus by targeting HIF1A

...from systemic lupus erythematosus patients, tissue with high T cell infiltration had higher protein levels pyruvate dehydrogenase kinase...
BioCentury | Feb 8, 2019
Product R&D

Reducing R(i)SK in TNBC

...sits at a major convergence point of two signaling pathways: the MAPK-MEK pathway, and the PDK...
...signal of RSK2 activation. Source: Phoenix Molecular Designs MAPK (ERK) - MAP kinase; PDK - pyruvate dehydrogenase kinase...
...Poly(ADP-ribose) polymerase PD-L1 (B7-H1; CD274) - Programmed cell death 1 ligand 1 PDK - Pyruvate dehydrogenase kinase...
BioCentury | Nov 15, 2018
Product R&D

Tempest takes PPAR alpha into cancer

...IDO1 - Indoleamine 2,3-dioxygenase 1 PD-1 (PDCD1; CD279) - Programmed cell death 1 PDK4 - Pyruvate dehydrogenase kinase...
BioCentury | Oct 20, 2018
Product Development

CVOT damage in diabetes

...GLP-1R; Glucose-dependent insulinotropic polypeptide (GIP) receptor Insulin secretion pathway Unknown SAR438335 Peptide Sanofi (Euronext:SAN; NYSE:SNY) Pyruvate dehydrogenase kinase (PDK)...
BioCentury | Feb 17, 2017
Targets & Mechanisms

Gilding the Goldfinch

In launching Goldfinch Biopharma Inc. , Third Rock is extending its already heavy footprint in precision medicine into chronic kidney disease. The VC thinks the unfolding genetics in that field can yield disease-modifying therapies and a...
BioCentury | Aug 18, 2016
Distillery Therapeutics

Therapeutics: Phosphoinositide 3-kinase α (PI3Kα); pyruvate dehydrogenase kinase 1 (PDK1); serum/glucocorticoid regulated kinase 1 (SGK1)

...testing to treat head and neck cancer and solid tumors. TARGET/MARKER/PATHWAY: Phosphoinositide 3-kinase α (PI3Kα); pyruvate dehydrogenase kinase...
BioCentury | Feb 11, 2016
Translation in Brief

Sugar rush

...microenvironment by modulating metabolism in tumors. Preclinical data for the lead compound - the tumor-targeted pyruvate dehydrogenase kinase (PDK)...
...According to Kolb, cancer cells often turn up their rate of glycolytic fermentation by up-regulating PDK...
...glucose and secrete lactate into the microenvironment, fostering the tumor's rapid growth. He added tumor PDK...
BioCentury | Dec 17, 2015
Distillery Therapeutics

Therapeutics: Pyruvate dehydrogenase kinase 2 (PDK2); PDK4

...include investigating the role of PDK2, PDK4 and other PDKs in additional pain models. TARGET/MARKER/PATHWAY: Pyruvate dehydrogenase kinase...
BioCentury | May 22, 2014
Distillery Therapeutics

Indication: Cardiovascular disease

...Indication Target/marker/pathway Summary Licensing status Publication and contact information Cardiovascular disease Restenosis Pyruvate dehydrogenase kinase 2 (PDK2) Rodent...
BioCentury | Dec 19, 2013
Distillery Techniques

Technology: Drug platforms

...and unrelated kinases. In cultured cells, staralogs inhibited analog-sensitive variants of EPH receptor A4 (EPHA4), pyruvate dehydrogenase kinase...
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