BioCentury | Jan 28, 2016
Distillery Therapeutics

Therapeutics: Pyrimidinergic receptor P2Y G protein-coupled 6 (P2RY6; P2Y6)

...Cardiovascular disease INDICATION: Hypertension Cell culture and mouse studies suggest inhibiting P2RY6 could help treat hypertension...
...and vascular fibrosis compared with normal P2RY6 expression. Next steps include testing the effect of P2RY6...
...remodeling in mouse models of heart failure. TARGET/MARKER/PATHWAY: Pyrimidinergic receptor P2Y G protein-coupled 6 (P2RY6; P2Y6...
BioCentury | Jan 20, 2011
Distillery Therapeutics

Indication: Inflammation

...Inflammation Purinergic receptor P2Y G protein-coupled 6 (P2RY6; P2Y6) Studies in mice suggest that inhibiting P2Y6...
...could help treat vascular inflammation. In a mouse model of lipopolysaccharide (LPS)-induced vascular inflammation, a P2Y6...
...antagonist lowered levels of a proinflammatory neutrophil cytokine in serum compared with vehicle control. In P2y6-deficient...
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