BioCentury | Aug 1, 2020
Product Development

July 31 Quick Takes: FDA approves MorphoSys’ tafasitamab; Truvian, AbbVie, Boehringer, Lilly, Alector, Henlius-Accord, Ascletis, Roche, Merck

MorphoSys follows Kress’ first big deal with U.S. approval FDA granted accelerated approval to Monjuvi tafasitamab-cxix from MorphoSys AG (Xetra:MOR; NASDAQ:MOR) and Incyte Corp. (NASDAQ:INCY) in combination with lenalidomide to treat patients with relapsed or...
BioCentury | Mar 26, 2020
Product Development

COVID-19 roundup: Grifols partners with BARDA, FDA on convalescent plasma; plus Vir, Sorrento, Ascletis, BMS and Ipsen

On the heels of FDA guidance for compassionate use of convalescent plasma for COVID-19, Grifols announced on Wednesday a partnership with the U.S. government to develop the therapy. Meanwhile, Vir and Sorrento are advancing their...
BioCentury | Mar 14, 2020
Translation in Brief

A peptide fusion blocker for multiple coronaviruses, the cryo-EM structure of SARS-CoV-2 main protease, plus Locus, Excision and Harvard-Dana-Farber

Fudan University develops pan-coronavirus inhibitor A team led by Fudan University researchers has developed a lipopeptide-based pan-coronavirus inhibitor of viral membrane fusion. Described in a preprint on the bioRxiv server, the lipopeptide binds the SARS-CoV-2...
BioCentury | Mar 11, 2020
Product Development

COVID-19 patients on Ascletis’ HCV drug discharged; plus Mesoblast allogeneic stem cells for COVID-19, Acceleron, Bridge-Atomwise, Cellectis and Abpro

Eleven COVID-19 patients discharged after receiving Ascletis drug Ascletis Pharma Inc. (HKEX:1672) said all 11 COVID-19 patients in a cohort receiving Ganovo danoprevir plus ritonavir in a Chinese Phase IV trial have been discharged from...
BioCentury | Jan 30, 2020
Company News

China guidelines point to HIV protease inhibitors as potential coronavirus treatment

Ascletis is seeking the approval of China’s NMPA for emergency use of its protease inhibitors to treat 2019-nCoV coronavirus after the government released guidelines suggesting AbbVie’s Kaletra as a treatment for the virus. In a...
BioCentury | Jan 25, 2020
Tools & Techniques

Manufacturing roundup: Deerfield launches new CDMO, plus a gene/cell therapy JV and more

...Jan. 14, ASC Therapeutics partnered with Vigene Biosciences Inc., a Maryland-based CDMO that will provide ASC...
...& Co. KGaA Bellicum Pharmaceuticals Inc. University of Texas MD Anderson Cancer Center Nationwide Children's Hospital BridgeBio Pharma Inc. Catalent Inc. ASC...
BioCentury | Oct 3, 2019
Product Development

Kidney is the new liver: why kidney indications are coming into sharp focus

...and renal disease, respectively. ZyVersa also is exploring inflammatory pathways with its inflammasome inhibitors targeting ASC...
BioCentury | Aug 16, 2019
Targets & Mechanisms

Biotechs explore the next generation of inflammasome targets, with caution

...up of a distinct sensor molecule, which detects pathogenic molecules, and the conserved adaptor molecule ASC...
...least one other company, ZyVersa, is going after the adaptor molecule ASC. ZyVersa licensed an anti-ASC...
...Zyversa Therapeutics Inc., Weston, Fla. Targets AIM2 - Absent in melanoma 2 ASC (PYCARD) - PYD and CARD domain containing...
BioCentury | Apr 22, 2019
Company News

Variant expands pipeline with InflamaCore inflammasome deal

...Weston, Fla.) also gained rights to develop companion diagnostics for the mAb targeting the adaptor PYCARD...
...Miami professors Robert Keane, W. Dalton Dietrich and Juan Pablo de Rivero Vaccari reported that PYCARD...
...NLR family pyrin domain containing 3; PYCARD (ASC) - PYD and CARD domain containing Chris Lieu, Staff Writer Variant Pharmaceuticals Inc. PYD and CARD domain containing (PYCARD) (ASC) Multiple...
BioCentury | Apr 12, 2019
Product Development

NLRP3 early and often

...as a variety of other internal stressors and environmental insults. Activated NLRP3 recruits adaptor protein PYCARD...
...Interleukin-18; NLRP3 (NALP3; CIAS1) - NLR family pyrin domain containing 3; PYCARD (ASC) - PYD and CARD domain containing...
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