BioCentury | Jun 2, 2016
Distillery Therapeutics

Therapeutics: P. falciparum dihydroorotate dehydrogenase (PfDHODH); P. vivax dihydroorotate dehydrogenase (PvDHODH)

...Infectious disease INDICATION: Malaria In vitro and mouse studies identified triazolopyrimidine-based inhibitors of PfDHODH and PvDHODH...
...and in vitro testing of triazolopyrimidine analogs identified three compounds that bound to PfDHODH and PvDHODH...
...and testing the compounds in models of malaria infection. TARGET/MARKER/PATHWAY: P. falciparum dihydroorotate dehydrogenase (PfDHODH); P. vivax dihydroorotate dehydrogenase (PvDHODH)...
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