BioCentury | Aug 28, 2020
Distillery Therapeutics

Preventing thrombosis using nanoparticles loaded with anti-G protein peptides

...delayed occlusive thrombosis; and synergized with aspirin plus generic P2RY12...
...GNA13); integrin β3 (GPIIIa; CD61); purinergic receptor P2Y G protein-coupled 12 (P2RY12; P2Y12)EXPERIMENTAL...
BioCentury | Jul 10, 2020
Product Development

Evive meets in Phase III for chemotherapy-induced neutropenia; plus regulatory updates for Biogen, Eisai, Merck, AZ

...had an acute ischemic stroke or a transient ischemic attack. The PDUFA date for the P2RY12...
BioCentury | Jun 2, 2020
Regulation

June 1 Quick Takes: CHMP recommendations, plus FDA action on AbbVie-Neurocrine, Shionogi, AZ, Lilly, Genentech

...stroke in high-risk patients with coronary artery disease. In the Phase III THEMIS trial, the P2RY12...
...Epidermal growth factor receptor 2 NTRK (Trk) - Neurotrophic tyrosine kinase receptor P2RY12 (P2Y12) - Purinergic receptor P2Y G protein-coupled 12...
...RG6268, rxdx-101) Johnson & Johnson Novartis AG AbbVie Inc. Neurocrine Biosciences Inc. Shionogi & Co. Ltd. AstraZeneca plc Eli Lilly and Co. Genentech Inc. Roche Purinergic receptor P2Y G protein-coupled 12 (P2RY12) (P2Y12) Epidermal...
BioCentury | Mar 1, 2019
Clinical News

Brilinta reduces CV events in patients without prior heart attack, stroke

...patients with acute coronary syndrome (ACS) or a history of MI. The reversible purinergic receptor P2Y G protein-coupled 12 (P2RY12; P2Y12...
...NYSE:AZN), London, U.K. Product: Brilinta ticagrelor Business: Cardiovascular Molecular target: Purinergic receptor P2Y G protein-coupled 12 (P2RY12; P2Y12) Description: Reversible P2RY12...
...Status: Phase III data Milestone: Additional Phase III data (2019) Chris Lieu Brilinta, Brilique, ticagrelor (AZD6140, Possia) AstraZeneca plc Purinergic receptor P2Y G protein-coupled 12 (P2RY12) (P2Y12)...
BioCentury | Feb 25, 2019
Clinical News

Brilinta reduces CV events in patients without prior heart attack, stroke

...patients with acute coronary syndrome (ACS) or a history of MI. The reversible purinergic receptor P2Y G protein-coupled 12 (P2RY12; P2Y12...
...P2RY12; P2Y12) inhibitor is marketed in the EU as Brilique. Chris Lieu Brilinta, Brilique, ticagrelor (AZD6140, Possia) AstraZeneca plc Purinergic receptor P2Y G protein-coupled 12 (P2RY12) (P2Y12)...
BioCentury | Feb 1, 2019
Company News

AZ, UPMC in value-based agreement for Brilinta

...at a concentration of 60 or 90 mg per tablet. Brilinta, a reversible purinergic receptor P2Y G protein-coupled 12 (P2RY12; P2Y12...
...of Pittsburgh Medical Center, Pittsburgh, Pa. Business: Cardiovascular Chris Lieu Brilinta, Brilique, ticagrelor (AZD6140, Possia) AstraZeneca plc University of Pittsburgh Purinergic receptor P2Y G protein-coupled 12 (P2RY12) (P2Y12) Acute...
BioCentury | Jan 28, 2019
Company News

AZ, UPMC in value-based agreement for Brilinta

...at a concentration of 60 or 90 mg per tablet. Brilinta, a reversible purinergic receptor P2Y G protein-coupled 12 (P2RY12; P2Y12...
...how their drugs work in the real-world setting. Chris Lieu Brilinta, Brilique, ticagrelor (AZD6140, Possia) AstraZeneca plc University of Pittsburgh Purinergic receptor P2Y G protein-coupled 12 (P2RY12) (P2Y12) Acute...
BioCentury | Dec 21, 2018
Clinical News

Idorsia's P2RY12 antagonist inhibits platelet aggregation within 15 minutes

...plans to meet with regulatory authorities to discuss Phase III testing of the purinergic receptor P2Y G protein-coupled 12 (P2RY12; P2Y12...
...dose-dependent inhibition of platelet aggregation can be seen two hours after single oral doses of P2RY12...
...Ltd. (SIX:IDIA), Allschwil, Switzerland Product: Selatogrel (ACT-246475) Business: Cardiovascular Molecular target: Purinergic receptor P2Y G protein-coupled 12 (P2RY12; P2Y12) Description: P2RY12...
BioCentury | Nov 9, 2018
Company News

AZ looks to new medicines to drive growth

...growth factor receptor (EGFR) (ErbB1) (HER1) Poly(ADP-ribose) polymerase (PARP) Programmed cell death 1 ligand 1 (PD-L1) (B7-H1) (CD274) Purinergic receptor P2Y G protein-coupled 12 (P2RY12) (P2Y12) Sodium-glucose...
BioCentury | Nov 8, 2018
Company News

AZ looks to new medicines to drive growth

...growth factor receptor (EGFR) (ErbB1) (HER1) Poly(ADP-ribose) polymerase (PARP) Programmed cell death 1 ligand 1 (PD-L1) (B7-H1) (CD274) Purinergic receptor P2Y G protein-coupled 12 (P2RY12) (P2Y12) Sodium-glucose...
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