BC Innovations | Aug 13, 2015
Translation in Brief

Pain's he said/she said

Neurology Most preclinical studies are performed in male animals, but a new study suggests entirely different targets, pathways and cell types could be responsible for mechanical pain in males and females, and provides clues about...
BC Innovations | Nov 8, 2012
Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Pain; spinal cord injury (SCI) Purinergic receptor P2X ligand-gated ion channel 4 (P2RX4) An SAR study identified P2RX4 antagonists that could be useful for treating...
BC Innovations | Mar 15, 2012
Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Spinal cord injury (SCI) Purinergic receptor P2X ligand-gated ion channel 4 (P2RX4; P2X4) Mouse studies suggest inhibiting P2X4 could help improve recovery following SCI. In...
BC Innovations | Jul 1, 2010
Distillery Therapeutics

Indication: Inflammation

Indication Target/marker/pathway Summary Licensing status Publication and contact information Inflammation Inflammation Purinergic receptor P2X ligand-gated ion channel 4 (P2X4; P2RX4); prostaglandin E2 (PGE2) A study in mice suggests that inhibiting P2RX4 could help treat inflammatory...
BC Innovations | Mar 18, 2010
Distillery Therapeutics

Indication: Cardiovascular disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cardiovascular disease Heart failure Purinergic receptor P2X ligand-gated ion channel 4 (P2RX4; P2X4) A study in mice identified phosphonate-based activators of P2X4 that could help treat...
BC Innovations | Mar 26, 2009
Distillery Therapeutics

Indication: Neurology

This week in therapeutics Indication Target/marker/ pathway Summary Licensing status Publication and contact information Neurology Nerve damage; pain Purinergic receptor P2X ligand-gated ion channel 4 (P2RX4); mitogen-activated protein kinase 14 (MAPK14; p38); brain-derived neurotrophic factor...
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