07:00 , Sep 27, 2012 |  BC Innovations  |  Distillery Therapeutics

Indication: Infectious disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease Leishmaniasis Dihydrofolate reductase (DHFR); pteridine reductase (PTR1) Cell culture studies identified piperidine-pteridine-based PTR1 inhibitors that could help circumvent antifolate drug resistance associated with Leishmania...
08:00 , Jan 13, 2011 |  BC Innovations  |  Distillery Therapeutics

Indication: Infectious disease

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease Leishmaniasis Pteridine reductase (PTR1); dihydrofolate reductase (DHFR) In vitro studies identified antifolate inhibitors of Leishmania major Ptr1 that could be...
08:00 , Feb 21, 2008 |  BC Innovations  |  Distillery Therapeutics

This Week in Therapeutics

This week in therapeutics Infectious disease Leishmaniasis; African sleeping sickness Pteridine reductase (PTR1); dihydrofolate reductase (DHFR) In vitro studies suggest that simultaneously antagonizing two folate reductase enzymes, PTR1 and DHFR, could be more useful for...