00:16 , Jul 26, 2019 |  BC Innovations  |  Translation in Brief

GI infection as Parkinson’s trigger

A Canadian team has shown how bacterial GI infections can trigger Parkinson's disease in genetically susceptible individuals. The findings add to mounting evidence implicating the gut microbiome in CNS disorders including autism, Alzheimer's disease and...
22:01 , Apr 4, 2017 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Parkinson’s disease (PD) Cell culture studies identified prodrugs of the PINK1 agonist kinetin riboside triphosphate that could help treat PD. The prodrugs were kinetin riboside phosphorothioate-based compounds that were cleaved by cellular esterases and...
07:00 , Jul 17, 2014 |  BC Innovations  |  Cover Story

Fixing mitophagy in Parkinson's disease

Genentech Inc. has identified ubiquitin specific peptidase 30 as a potentially disease-modifying target involved in the clearance of damaged mitochondria in Parkinson's disease. 1 The Roche unit now needs to determine whether the deubiquitinase is...
07:00 , Sep 12, 2013 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Parkinson's disease (PD) PTEN induced putative kinase 1 (PINK1) In vitro and cell culture studies suggest activating PINK1 could help treat...
07:00 , Sep 12, 2013 |  BC Innovations  |  Targets & Mechanisms

All in the family

PTEN induced putative kinase 1 is a tantalizing player in familial forms of Parkinson's disease, in which it is inactivated by mutation, but thus far the kinase has been a no-fly zone for drug development...
08:00 , Nov 29, 2012 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Parkinson's disease (PD) Nitric oxide (NO); PTEN induced putative kinase 1 (PINK1) Cell culture studies suggest restoring NO signaling could help correct mitochondrial dysfunction in...
07:00 , Aug 16, 2012 |  BC Innovations  |  Distillery Techniques

Technology: Disease models

Approach Summary Licensing status Publication and contact information Disease models Induced pluripotent stem (iPS) cell-derived neurons from patients with familial Parkinson's disease (PD) iPS cell-derived neurons from patients with PD may help characterize disease phenotypes...
07:00 , Oct 22, 2009 |  BC Innovations  |  Cover Story

Rat race in PD

The Michael J. Fox Foundation for Parkinson's Research didn't waste any time putting recently published knockout rat technology to work. 1,2 The foundation and Sigma-Aldrich Corp. have partnered to develop models of Parkinson's disease and...
07:00 , Mar 26, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

This week in therapeutics Indication Target/marker/ pathway Summary Licensing status Publication and contact information Neurology Parkinson's disease (PD) PTEN induced putative kinase 1 (PINK1) A study in murine and human cell culture suggests that increasing...
08:00 , Mar 5, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

This week in therapeutics Indication Target/marker/ pathway Summary Licensing status Publication and contact information Neurology Parkinson's disease (PD) Parkinson disease (autosomal recessive, juvenile) 2 parkin (PARK2; Parkin); PTEN induced putative kinase 1 (PINK1); DJ-1 (PARK7);...