BioCentury | Jun 23, 2020
Product Development

June 22 Quick Takes: Invitae acquiring ArcherDX; plus lymphoma approval for Karyopharm, Merck, Nabriva, Myovant, Assembly-AbbVie, Genentech and more

...progression-free survival (PFS) vs. standard of care plus placebo in a subpopulation of patients with PTEN...
...Tumor necrosis factor receptor superfamily member 17 GNRHR - GnRH/LHRH receptor PTEN (MMAC1; TEP1) - Phosphatase and tensin homolog deleted on chromosome ten BioCentury...
BioCentury | Dec 9, 2019
Company News

With $2.7B ArQule buyout, Merck is latest pharma to jump into Btk race

...751, which is in Phase Ib testing to treat solid tumors harboring AKT, PIK3CA or PTEN...
BioCentury | Oct 24, 2019
Preclinical News

Oct. 24 Preclinical Quick Takes: anti-neuraminidase human antibodies for broad flu protection; plus Ionis-Baylor, Merck and more

...therapy against RICTOR that could treat neurological disorders, including seizures and autism, caused by loss-of-function PTEN...
...ASO reduced seizures and autism-associated social behaviors and improved long-term memory in mice with forebrain-specific PTEN...
...Low-density lipoprotein receptor; PCSK9 - Proprotein convertase subtilisin/kexin type 9; PTEN (MMAC1; TEP1) - Phosphatase and tensin homolog deleted on chromosome ten...
BioCentury | Jul 26, 2019
Translation in Brief

GI infection as Parkinson’s trigger

...PTEN induced putative kinase 1; SNCA - α synuclein Sandi Wong, Staff Writer McGill University University of Montreal Parkin (PARK2) PTEN...
BioCentury | Apr 22, 2019
Distillery Therapeutics

The former diabetes drug phenformin for T cell ALL

...and mouse studies suggest phenformin could help treat PTEN-deficient T cell ALL. In three mouse PTEN-deficient...
...was withdrawn from the market in 1978 due to lactic acidosis. TARGET/MARKER/PATHWAY: Phosphatase and tensin homolog deleted on chromosome ten (PTEN; MMAC1; TEP1...
...University of Dundee, Scotland, U.K. email: d.g.hardie@dundee.ac.uk Claire Quang University of Dundee Mitochondrial complex 1 (MC-1) Phosphatase and tensin homolog deleted on chromosome ten (PTEN) (MMAC1) (TEP1) Acute...
BioCentury | Feb 1, 2019
Company News

Lung-MAP expands to include all advanced NSCLC patients

SWOG's Lung Cancer Master Protocol (Lung-MAP) precision medicine trial is implementing new protocols and expanding to include all advanced stage non-small cell lung cancer patients, moving beyond its initial population of advanced stage squamous cell...
BioCentury | Jan 29, 2019
Clinical News

Lung-MAP expands to include all advanced NSCLC patients

SWOG's Lung Cancer Master Protocol (Lung-MAP) precision medicine trial is implementing new protocols and expanding to include all advanced stage non-small cell lung cancer patients, moving beyond its initial population of advanced stage squamous cell...
BioCentury | Jan 4, 2019
Tools & Techniques

Making AD mice as diverse as patients

...group from Texas A&M University used UNC’s mice to pinpoint modifiers of the cancer driver PTEN...
...ε4 APP - Amyloid precursor protein PSEN1 (PS1) - Presenilin 1 PTEN (MMAC1; TEP1) - Phosphatase and tensin homolog deleted on chromosome ten Allison...
...E (APOE) Apolipoprotein E (APOE) epsilon 4 (APOE4) Beta amyloid Microtubule-associated protein tau (tau) (MAPT) (FTDP-17) Phosphatase and tensin homolog deleted on chromosome ten (PTEN) (MMAC1) (TEP1) Presenilin...
BioCentury | Dec 11, 2018
Distillery Therapeutics

Cancer

...Prostate cancer Cell culture, patient sample and mouse studies suggest inhibiting SMARCA4 could help treat PTEN-deficient...
...of PTEN, high tumor levels of SMARCA4 were associated with poor survival. In three human PTEN-deficient...
...associated actin dependent regulator of chromatin subfamily a member 4 (SMARCA4; BRG1); phosphatase and tensin homolog deleted on chromosome ten (PTEN; MMAC1; TEP1...
BioCentury | Oct 31, 2018
Distillery Therapeutics

Cancer

...or in combination with PI3K could help treat PTEN-deficient triple-negative breast cancer (TNBC). In a PTEN-deficient...
...PI3K inhibitor tool compound increased cell death compared with either agent alone. In two additional PTEN-deficient...
...of PTEN-deficient TNBC. TARGET/MARKER/PATHWAY: Lysine-specific demethylase 4B (KDM4B; JMJD2B); phosphoinositide 3-kinase (PI3K); phosphatase and tensin homolog deleted on chromosome ten (PTEN; MMAC1; TEP1...
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