16:38 , Jul 18, 2019 |  BC Innovations  |  Distillery Techniques

David Liu uses anionic human protein for efficient cellular delivery of gene editing proteins

TECHNIQUES CATEGORY: Drug Delivery TECHNOLOGY: Peptides; nanoparticles David Liu's team improved delivery of liposomally packaged gene editing proteins into mammalian cells by fusing the proteins to prothymosin α (PTMA). A screen in HeLa cells, in...
22:22 , Jul 12, 2019 |  BC Extra  |  Preclinical News

July 12 Preclinical Quick Takes: Feng Zhang develops latest RNA editing platform, plus tools from David Liu and NIH

Zhang's RESCUE platform converts RNA C to U bases  Feng Zhang and colleagues at Massachusetts Institute of Technology and the Broad Institute of MIT and Harvard have developed a single base RNA editing system that...
22:11 , Apr 13, 2017 |  BC Innovations  |  Targets & Mechanisms

Cool and also collected

A Nature Medicine study published this week shows the immune-modulating peptide thymosin α1 provides unexpected improvements in the dysfunctional ion channel that causes cystic fibrosis, and could lead to a single agent therapy to compete...
20:04 , Apr 11, 2017 |  BC Innovations  |  Distillery Therapeutics

Pulmonary; infectious disease

INDICATION: Cystic fibrosis (CF); fungal infection Patient sample and mouse studies suggest the PTMA -derived peptide thymosin α1 could help treat CF and CF-related pulmonary fungal infections. In primary bronchial epithelial cells from five CF...
07:00 , May 20, 2010 |  BC Innovations  |  Distillery Therapeutics

Indication: Infectious disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease HIV/AIDS Prothymosin-a (PTMA); toll-like receptor 4 (TLR4) A study in cell culture suggests that increasing PTMA levels could help treat HIV-1 infection. In infected...
08:00 , Jan 13, 2003 |  BC Week In Review  |  Company News

Abbott other research news

Researchers published in Science that PETCM activates caspase-3 by driving formation of the apoptosome, a multi-protein complex that initiates the apoptosis cascade. Specifically, PETCM disrupted the activity of prothymosin-alpha, which negatively regulates apoptosis by inhibiting...