BioCentury | Aug 28, 2020
Emerging Company Profile

Concarlo: targeting proliferation and resistance in one go

...CDKN1B) – cyclin-dependent kinase inhibitor 1BPTK6 – protein tyrosine kinase...
BioCentury | Oct 26, 2019
Product Development

How a KRAS program transformed Mirati's story

...1 SHP-2 (SHPTP2; PTPN11) - Src homology protein tyrosine phosphatase 2 TYRO3 (Sky) - TYRO3 protein tyrosine kinase Lauren...
BioCentury | Aug 1, 2019
Distillery Therapeutics

A pyrrolopyrimidine-based TYRO3 inhibitor for primary effusion lymphoma

...inhibitor as well as inhibitors of related kinases and developing them for cancer. TARGET/MARKER/PATHWAY: TYRO3 protein tyrosine kinase...
...Blossom Damania, same affiliation as above email: damania@med.unc.edu Claire Quang University of North Carolina at Chapel Hill TYRO3 protein tyrosine kinase...
BioCentury | Jul 3, 2019
Preclinical News

Controlling CAR T toxicity with BMS's Sprycel

...CAR T cell activity. The BCR-ABL tyrosine kinase (BCR-ABL) and Src kinase inhibitor blocks lymphocyte-specific protein tyrosine kinase...
...ALL) and chronic myelogenous leukemia (CML). Targets: BCR-ABL - BCR-ABL tyrosine kinase; LCK - Lymphocyte-specific protein tyrosine kinase Sandi...
BioCentury | Mar 29, 2019
Targets & Mechanisms

Next-wave targets at AACR 2019 start filling the blanks in the tumor microenvironment

...TNFRSF1B) - Tumor necrosis factor receptor 2 TOP2 - Topoisomerase II TYRO3 (Sky) - TYRO3 protein tyrosine kinase Karen...
BioCentury | Feb 8, 2019
Company News

BioMotiv, Rutgers launch TamRx

...GAS6 - Growth arrest-specific 6; MERTK - c-Mer proto-oncogene tyrosine kinase; TYRO3 (Sky) - TYRO3 protein tyrosine kinase...
...Zipkin BioMotiv LLC Rutgers University AXL receptor tyrosine kinase (AXL) (UFO) c-Mer proto-oncogene tyrosine kinase (MERTK) Growth arrest-specific 6 (GAS6) TYRO3 protein tyrosine kinase...
BioCentury | Feb 7, 2019
Company News

BioMotiv, Rutgers launch TamRx

...GAS6 - Growth arrest-specific 6; MERTK - c-Mer proto-oncogene tyrosine kinase; TYRO3 (Sky) - TYRO3 protein tyrosine kinase Mark...
...Zipkin BioMotiv LLC Rutgers University AXL receptor tyrosine kinase (AXL) (UFO) c-Mer proto-oncogene tyrosine kinase (MERTK) Growth arrest-specific 6 (GAS6) TYRO3 protein tyrosine kinase...
BioCentury | Oct 26, 2018
Clinical News

Mirati reports updated confirmed ORR of 16% in Phase II of sitravatinib for NSCLC

...Sitravatinib is a spectrum-selective kinase inhibitor that inhibits multiple RTKs, including ret proto-oncogene (RET), TYRO3 protein tyrosine kinase...
...NASDAQ:MRTX), San Diego, Calif. Product: Sitravatinib (MGCD516) Business: Cancer Molecular target: Ret proto-oncogene (RET); TYRO3 protein tyrosine kinase...
...Generic), Opdivo (Other) Sitravatinib (MGCD516, mg516) BeiGene Ltd. Mirati Therapeutics Inc. AXL receptor tyrosine kinase (AXL) (UFO) Ret proto-oncogene (RET) TYRO3 protein tyrosine kinase...
BioCentury | Oct 22, 2018
Clinical News

Mirati falls on updated response data for sitravatinib in NSCLC

...Sitravatinib is a spectrum-selective kinase inhibitor that inhibits multiple RTKs, including ret proto-oncogene (RET), TYRO3 protein tyrosine kinase...
...Therapeutics Inc. AXL receptor tyrosine kinase (AXL) (UFO) Programmed cell death 1 (PD-1) (PDCD1) (CD279) Ret proto-oncogene (RET) TYRO3 protein tyrosine kinase...
BioCentury | Oct 2, 2018
Company News

FDA approves Paratek antibiotics

...$9.24 on Tuesday. Almirall slipped €0.84 to €19.96. Allergan gained $1.09 to $193.42. BC Staff omadacycline (ZL-2401, ptk...
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