07:00 , May 11, 2015 |  BioCentury  |  Emerging Company Profile

Preventing accumulation

InFlectis BioScience S.A.S. is developing preclinical small molecules for Orphan diseases to slow production of misfolded proteins whose accumulation leads to disease. The goal is to turn up one of the three components of the...
07:00 , Apr 23, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Protein phosphatase 1 regulatory inhibitor subunit 15A (PPP1R15A; PEG-3); eukaryotic translation initiation factor 2 (eIF2) subunit 1α (eIF-2α; EI

Neurology INDICATION: Amyotrophic lateral sclerosis (ALS); neuropathy In vitro and mouse studies suggest a selective inhibitor of PPP1R15A - the regulatory subunit of eIF-2α - could help treat ALS, Charcot-Marie-Tooth disease and other diseases involving...
07:00 , Mar 24, 2011 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Neurology Protein phosphatase 1 regulatory inhibitor subunit 15A (PPP1R15A; PEG-3) An in vitro study suggests that the generic antihypertensive guanabenz could...
08:00 , Jan 13, 2011 |  BC Innovations  |  Cover Story

Taking cancer imaging up a PEG

Researchers at The Johns Hopkins University and Virginia Commonwealth University have developed a new method for imaging primary and metastatic tumors that may be broadly useful across multiple cancers. 1 The lead investigators have founded...
08:00 , Jan 13, 2011 |  BC Innovations  |  Distillery Techniques

Technology: Imaging

This week in techniques Approach Summary Licensing status Publication and contact information Imaging Protein phosphatase 1 regulatory inhibitor subunit 15A (Ppp1r15a; Peg-3) promoter-based tumor imaging Peg-3 promoter-based imaging could be used to detect primary and...