BioCentury | Sep 14, 2017
Targets & Mechanisms

Platelets YAP at cancer

...like YAP1 is challenging, but other proteins in the pathway, such as the MYPT1 - PPP1CC...
...MD Anderson Cancer Center . Table: BIOCENTURY PRODUCT PROFILE BIOCENTURY PRODUCT PROFILE INNOVATION STAGE Product MYPT1-PPP1CC...
...the response of the cancer cells to platelets is regulated by dephosphorylation through the RHOA -MYPT1-PPP1CC...
BioCentury | Sep 13, 2017
Distillery Therapeutics

Cancer

...of peritoneal metastases compared with scrambled siRNA. Next steps include identifying inhibitors of MYPT1 and PPP1CC...
...protein phosphatase 1 regulatory subunit 12A (MYPT1; PPP1R12A); protein phosphatase 1 catalytic subunit γ isoform (PPP1CC...
...MD Anderson Cancer Center, Houston, Texas email: asood@mdanderson.org Michael Leviten University of Texas MD Anderson Cancer Center Protein phosphatase 1 catalytic subunit gamma isoform (PPP1CC) Protein...
BioCentury | Nov 5, 2015
Distillery Therapeutics

Therapeutics: Calcineurin; calcineurin A γ (PPP3CC; CNA3)

Endocrine/metabolic disease INDICATION: Contraception Mouse studies suggest PPP3CC inhibition could be used for male contraception. In normal male mice, PPP3CC knockout decreased sperm motility and fertility compared with normal PPP3CC expression. Also in normal male...
BioCentury | May 28, 2009
Targets & Mechanisms

New angiogenesis targets

...Endothal, a generic herbicide; cantharidin and cantharidic acid, insect-derived toxins with in vitro antitumor activity PPP1CC...
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