BioCentury | Apr 22, 2019
Distillery Therapeutics

STAG2 identified as target in glioblastoma and Ewing sarcoma

...one of five genes involved in dsDNA break repair -- ATR, BRCA1, RAD51, XRCC5 or PRKDC...
...1 early onset (BRCA1); RAD51 homolog (RAD51); X-ray repair cross complementing 5 (XRCC5); protein kinase DNA-activated catalytic polypeptide (PRKDC; DNAPK...
...California San Francisco Ataxia telangiectasia and Rad3 related (ATR) (FRP1) Breast cancer 1 early onset (BRCA1) Protein kinase DNA-activated catalytic polypeptide (PRKDC) (DNAPK) RAD51...
BioCentury | Apr 13, 2018
Targets & Mechanisms

Meeting the burden

...March 14 Target 1 Target 2 Indication Abstract # DNA damage response (DDR) DDR MSH6 PRKDC...
BioCentury | Oct 24, 2013
Distillery Therapeutics

Indication: Cancer

...Target/marker/pathway Summary Licensing status Publication and contact information Cancer Prostate cancer Androgen receptor; protein kinase DNA-activated catalytic polypeptide (PRKDC; DNAPK...
...reversed the growth inhibitory effect of a DNAPK inhibitor plus radiation. Next steps include screening DNAPK...
BioCentury | May 26, 2011
Distillery Techniques

Technology: Drug platforms

...efficacy of radiation therapy. In an in vitro screen, small interfering RNA against protein kinase DNA-activated catalytic polypeptide (PRKDC; DNAPK...
...In a mouse model of prostate cancer, radiation plus intratumoral injection of an aptamer-shRNA targeting PRKDC...
BioCentury | Mar 17, 2011
Distillery Therapeutics

Indication: Cancer

...information Cancer Cancer Protein kinase DNA-activated catalytic polypeptide (PRKDC; DNAPK) In vitro studies suggest that a peptide inhibitor of PRKDC...
...early onset (BRCA1)-deficient breast cancer and/or BRCA2-deficient pancreatic cancer cell lines, a PRKDC-targeting peptide decreased PRKDC...
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