07:00 , Apr 21, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Protein inhibitor of activated STAT protein 1 (PIAS1); huntingtin (HTT)

Neurology INDICATION: Huntington's disease (HD) Mouse studies suggest inhibiting PIAS1 could help treat HD. In a mouse model of HD, intrastriatal injection of a viral vector encoding a PIAS1-targeting microRNA (miRNA) decreased striatal levels of...
07:00 , Oct 28, 2010 |  BC Innovations  |  Distillery Therapeutics

Indication: Autoimmune disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Autoimmune disease Autoimmune; multiple sclerosis (MS) Protein inhibitor of activated STAT 1 (PIAS1) Studies in mice suggest that inhibiting PIAS1 signaling could help treat MS and...
00:15 , Jun 9, 2007 |  BC Extra  |  Clinical News

Proinflammatory stimuli induce gene repression

Researchers from UCLA and colleagues reported in Cell the discovery of a signaling pathway by which extracellular proinflammatory stimuli signal the nucleus to repress inflammatory gene activation. The scientists found that ligand-induced phosphorylation of protein...