BioCentury | Sep 6, 2012
Targets & Mechanisms

Passenger mutations take the wheel

...the spliceosome, proteasome and the ribosome. The top hit was the gene encoding proteasome 26S subunit ATPase 2 ( PSMC2...
...potential of suppressing PSMC2 in vivo , the researchers used tumor-specific nanoparticles to deliver anti- PSMC2...
...family member 20B Chromosomal segregation Nijhawan et al. Gene abbreviation Encoded protein Cellular pathway PSMC2 Proteasome 26S subunit ATPase 2...
BioCentury | Sep 6, 2012
Distillery Therapeutics

Indication: Cancer

...Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer Proteasome 26S subunit ATPase 2 (PSMC2) Mouse studies suggest inhibiting PSMC2...
...cells could help treat cancer. In mouse xenograft models of ovarian cancer, tumor-targeted delivery of anti-PSMC2...
...of control siRNA (p<0.0001). Next steps could include screening for small molecules that selectively inhibit PSMC2...
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