BioCentury | Jan 25, 2020
Targets & Mechanisms

CAR T strategies for cracking the code in solid tumors

...MUC1) (CD227) Mucin 16 (MUC16) (CA125) Killer cell lectin-like receptor subfamily K member 1 (NKG2D) (KLRK1) (CD314) Prostate stem cell antigen (PSCA) Prostate-specific...
BioCentury | Jun 1, 2019
Product Development

ASCO 2019 abstracts show solid tumor race heating up among bispecifics and CAR Ts

...cell company Juno Therapeutics, which was acquired by Celgene Corp. in 2018. Bellicum’s CAR targets PSCA...
...cell death 1 PD-L1 (B7-H1; CD274) - Programmed cell death 1 ligand 1 PSCA - Prostate stem cell antigen...
...CD223) Programmed cell death 1 (PD-1) (PDCD1) (CD279) Programmed cell death 1 ligand 1 (PD-L1) (B7-H1) (CD274) Prostate stem cell antigen (PSCA) Silver...
BioCentury | Dec 21, 2018
Product R&D

Cell therapies seek solid ground

...Center / Celgene Corp. (NASDAQ:CELG) / Eureka Therapeutics Inc. JCAR020 Ovarian cancer Ph I Prostate stem cell antigen (PSCA...
BioCentury | Aug 1, 2018
Distillery Therapeutics

Cancer

...INDICATION: Pancreatic cancer Cell culture and mouse studies suggest T cells engineered to express an anti-PSCA...
...include testing the CAR T cells in additional animal models of pancreatic cancer. TARGET/MARKER/PATHWAY: Prostate stem cell antigen (PSCA...
...Hospital, Houston, Texas email: jfvera@txch.org Mark Zipkin Texas Children's Hospital Interleukin-4 (IL-4) receptor (CD124) (IL-4RA) Interleukin-7 (IL-7) receptor (CD127) Prostate stem cell antigen (PSCA) Tumor...
BioCentury | Mar 9, 2017
Clinical News

Rimiducid: Ph I BP-012 started

...2014 ). Bellicum’s BPX-061 is a chimeric antigen receptor (CAR) T cell therapy targeting prostate stem cell antigen (PSCA...
...recommended extension dose Status: Phase I started Milestone: NA Chris Lieu AP1903 BPX-601 rimiducid Bellicum Pharmaceuticals Inc. Takeda Pharmaceutical Co. Ltd. Prostate stem cell antigen (PSCA...
BioCentury | Mar 9, 2017
Clinical News

BPX-601: Ph I BP-012 started

...Business: Cancer Molecular target: Prostate stem cell antigen (PSCA) Description: Chimeric antigen receptor (CAR) T cell therapy targeting PSCA...
...recommended extension dose Status: Phase I started Milestone: NA Chris Lieu AP1903 BPX-601 rimiducid Bellicum Pharmaceuticals Inc. Takeda Pharmaceutical Co. Ltd. Prostate stem cell antigen (PSCA...
BioCentury | Dec 10, 2016
Product Development

Rules of the road

...programs in Phase I testing. Bellicum’s BPX-601 is a CAR T cell therapy targeting prostate stem cell antigen (PSCA...
BioCentury | Jul 18, 2016
Product Development

ROCKET resumes

...risk is to use CAR Ts with a suicide switch. Bellicum's BPX-601 targets the prostate stem cell antigen (PSCA...
BioCentury | May 12, 2014
Finance

Vivid imaging

...to an overexpression of PSMA. ImaginAb's early stage clinical pipeline includes antibody fragments targeting prostate stem cell antigen (PSCA...
BioCentury | Jan 16, 2014
Cover Story

Putting on the brakes

...finely tuned signaling," said Sadelain. In proof-of-concept studies, the MSKCC-Dresden group focused on prostate stem cell antigen ( PSCA...
...highly expressed in metastatic prostate cancer, although neither antigen is absolutely specific to prostate tissue. PSCA...
...PSCA + /PSMA - and PSCA - /PSMA + tumors, T cells expressing an attenuated, PSCA-specific...
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