BioCentury | May 30, 2020
Translation in Brief

Empirica’s glioblastoma CAR T therapy in mice; plus tumor microbiomes by tumor type, Senhwa and more

...paper proof-of-concept data for Empirica Therapeutics’ lead product eCAR-133, a CAR T cell therapy targeting PROM1...
...early onset PARP - Poly(ADP-ribose) polymerase PCBP1 - Poly(rC) binding protein 1 PROM1 (CD133) - Prominin 1 Danielle...
...Science McMaster University Empirica Therapeutics Medical University of South Carolina Senhwa Biosciences Inc. Breast cancer 1 early onset (BRCA1) Prominin 1 (PROM1) (CD133) Poly(rC...
BioCentury | Jan 10, 2020
Emerging Company Profile

Empirica: Building a new model for brain cancer

...cancer stem cell biomarker PROM1 with the recurrence model. Moffat also serves as Empirica’s CSO. PROM1...
...modalities head to head in the recurrence model to determine which is most effective. For PROM1...
...1 issued covering PROM1-binding agents Targets PROM1 (CD133) - Prominin 1 Elizabeth S. Eaton, Staff Writer Empirica Therapeutics Inc. PROM1...
BioCentury | May 4, 2018
Targets & Mechanisms

Solid hopes for T cell bispecifics

...at McMaster University reported on the design of a CAR and a BiTE that target PROM1...
...Glypican 3 PD-L1 (B7-H1; CD274) - Programmed cell death 1 ligand 1 PROM1 (CD133) - Prominin 1...
BioCentury | May 11, 2017
Tools & Techniques

Stemming the tide

...Cancer stem cell vaccine that stimulates a cytotoxic T lymphocyte response to promin 1 (PROM1; CD133...
...a mouse xenograft model of PDAC compared with vehicle June 2016 GD3 ganglioside; prominin 1 (PROM1; CD133...
...Glioblastoma Expression of GD3 ganglioside and its synthetic enzyme ST8SIA1 correlated with expression of the PROM1...
BioCentury | Aug 8, 2016
Clinical News

ICT-121: Completed Phase I enrollment

...disease. ImmunoCellular Therapeutics Ltd. (NYSE-M:IMUC), Calabasas, Calif. Product: ICT-121 Business: Cancer Molecular target: Prominin 1 (PROM1) (CD133...
...CD133) Description: Cancer stem cell vaccine that stimulates a cytotoxic T lymphocyte (CTL) response to prominin 1...
...Cancer stem cell vaccine that stimulates a cytotoxic T lymphocyte (CTL) response to prominin 1 (PROM1; CD133...
BioCentury | May 5, 2016
Distillery Therapeutics

Therapeutics: GD3 ganglioside; ST8 α-N-acetyl-neuraminide α-2,8-sialyltransferase 1 (ST8SIA1); prominin 1 (PROM1; CD133)

...cell lines, levels of GD3 ganglioside correlated with expression of the cancer stem cell marker PROM1...
...II testing to treat melanoma. TARGET/MARKER/PATHWAY: GD3 ganglioside; ST8 α-N-acetyl-neuraminide α-2,8-sialyltransferase 1 (ST8SIA1); prominin 1 (PROM1; CD133...
BioCentury | May 19, 2014
Emerging Company Profile

Curtana: Curtains for CSCs

...correlated with glioma stem cells identified by the progenitor cell marker prominin 1 ( PROM1 ; CD133...
BioCentury | Feb 13, 2014
Distillery Therapeutics

Indication: Cancer

...Publication and contact information Cancer Glioblastoma Epidermal growth factor receptor variant III (EGFRvIII); prominin 1 (PROM1; CD133...
...antibody targeting EGFRvIII and CD133 could help treat glioblastoma. In samples from patients with glioblastoma, CD133...
...tumor formation than cells expressing CD133 alone. In the mouse model, a bispecific antibody targeting CD133...
BioCentury | Aug 5, 2013
Clinical News

ICT-121: Phase I started

...disease. ImmunoCellular Therapeutics Ltd. (NYSE-M:IMUC), Calabasas, Calif. Product: ICT-121 Business: Cancer Molecular target: Prominin 1 (PROM1) (CD133...
...CD133) Description: Cancer stem cell vaccine that stimulates a cytotoxic T lymphocyte (CTL) response to CD133...
BioCentury | Feb 14, 2013
Distillery Therapeutics

Indication: Cancer

...information Cancer Cancer Prominin 1 (PROM1; CD133) Mouse studies suggest oncolytic measles viruses engineered to target CD133...
...CD133) Mouse studies suggest oncolytic measles viruses engineered to target CD133 could help treat cancer. CD133...
...and is highly expressed in many cancers. In mice bearing CD133-expressing human hepatocellular carcinoma, a CD133-targeted...
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