BioCentury | Jul 27, 2017
Translation in Brief

Cycling across the membrane

...to the nucleolus, which is not always desirable. The approach worked for GFP fused to proliferating cell nuclear antigen (PCNA)...
...when linked to the nanobody, the complex entered cells and released the cargo, which bound PCNA's...
...Molecular Pharmacology Technical University Darmstadt Mdm2 p53 binding protein homolog (MDM2) (HDM2) Methyl CpG binding protein 2 (MECP2) (RTT) Proliferating cell nuclear antigen (PCNA) Tumor...
BioCentury | Oct 9, 2014
Distillery Techniques

Technology: Disease models

...behaviors in the still-ligated models. Also after ligation removal in the models, hippocampal levels of proliferating cell nuclear antigen (PCNA)...
BioCentury | Apr 23, 2012
Emerging Company Profile

APIM: Besting the stress defense

...compound could improve the efficacy of approved drugs to treat multiple myeloma and other cancers. Proliferating cell nuclear antigen (PCNA)...
...by interacting with more than 200 proteins that contain the PCNA-interacting peptide (PIP box) motif. PCNA...
...well understood until researchers from the Norwegian University of Science and Technology (NTNU) reported that PCNA...
BioCentury | Mar 22, 2012
Distillery Therapeutics

Indication: Cancer

...the triiodothyronine T3 derivative PCNA inhibitor T2AA could help treat cancer. In vitro, T2AA inhibited PCNA...
...with no treatment. Next steps could include optimizing T2AA to generate lead compounds with higher PCNA...
BioCentury | Apr 20, 2009
Clinical News

AT7519: Phase I data

...2/day of IV AT7519 inhibited CDK as assessed by a reduction in phospho- nucleophosmin and proliferating cell nuclear antigen (PCNA)...
BioCentury | Dec 9, 2006
Clinical News

Breast cancer marker identified

...Proceedings of the National Academy of Sciences that they developed an antibody that detects a proliferating cell nuclear antigen...
BioCentury | Mar 14, 2005
Tools & Techniques

A different donut hole

...drugs to regulate PCNA function. "Many cancers are associated with an abnormally high level of PCNA...
...partner now suggests that p21 binds to PCNA like a double-sided sticky tape to hold PCNA...
...target site on the surface of PCNA that may be exploited in the design of PCNA...
BioCentury | Dec 22, 2003
Product Development

Around the circle

...that is induced by p53, acts by the dual binding of two distinct proteins: PCNA (proliferating cell nuclear antigen...
BioCentury | Apr 21, 2003
Clinical News

VIT100: Phase I

...San Diego, Calif. Product: VIT100 Business: Dermatology Molecular target: Proliferating cell nuclear antigen (PCNA) Description: Ribozyme-based inactivator of PCNA...
BioCentury | Aug 19, 2002
Clinical News

VitrenAse: Phase II

...Calif. Product: VitrenAse Business: Ophthalmology Therapeutic category: Antisense Target: Proliferating cell nuclear antigen (PCNA) gene Description: Ribozyme-based inactivator of PCNA...
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