BioCentury | Jun 18, 2015
Distillery Techniques

Techniques: Hybrid poly(D,L-lactide-co-glycolide) (PLGA) polymer/lipid nanoparticles for siRNA delivery

...tumors. Also in the NSCLC models, hybrid nanoparticles loaded with siRNA against prohibitin 1( PHB ; PHB1...
BioCentury | May 1, 2013
Financial News

Arrowhead to raise $36M in private placement

...to treat obesity. The compound is a peptidomimetic consisting of a prohibitin 1 ( PHB : PHB1...
BioCentury | Jul 16, 2012
Clinical News

Adipotide: Phase I started

...formerly Prohibitin-TP01 ) Business: Endocrine/Metabolic Molecular target: Prohibitin 1(PHB) (PHB1) Description: Peptidomimetic consisting of a prohibitin 1 (PHB; PHB1)-targeting...
BioCentury | Jul 9, 2012
Clinical News

Arrowhead preclinical data

...the American Diabetes Association. Adipotide is a peptidomimetic consisting of a prohibitin 1 ( PHB ; PHB1...
BioCentury | Jul 9, 2012
Strategy

Belviq breaks through

...protein (AGRP) Ph II Arrowhead Research Corp. (NASDAQ:ARWR) Adipotide Peptidomimetic consisting of a prohibitin 1 (PHB; PHB1...
BioCentury | Nov 17, 2011
Distillery Therapeutics

Indication: Endocrine/metabolic disease

...Publication and contact information Endocrine/metabolic disease Obesity Prohibitin 1 (PHB; PHB1) Nonhuman primate studies suggest a PHB1-binding...
BioCentury | Nov 17, 2011
Strategy

MD Anderson's private screening

...of Ablaris' lead compound adipotide , a peptidomimetic consisting of a prohibitin 1 ( PHB ; PHB1...
...proapoptotic helical peptide that disrupts mitochondrial membranes. The researchers found an annexin A2 ( ANXA2 )-PHB...
...the vasculature for normal white adipose tissues and showed that the targeting peptide domain of PHB...
BioCentury | Apr 11, 2011
Company News

Arrowhead endocrine news

...Ablaris when it launched the company late last year to commercialize technology related to targeting prohibitin 1 (PHB1)...
BioCentury | Jan 3, 2011
Company News

Arrowhead, M.D. Anderson Cancer Center deal

...The center granted Arrowhead an exclusive, worldwide license to technology related targeting the prohibitin 1 (PHB1) to treat...
BioCentury | Feb 4, 2010
Distillery Therapeutics

Indication: Cancer

...mouse studies suggest that inhibiting PHB1 could help treat paclitaxel-resistant cancers. Proteomics analysis showed that PHB1...
...with nonresistant cancer cell lines. In resistant cell lines and mice with resistant xenograft tumors, PHB1-targeting...
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