BioCentury | Sep 19, 2020
Translation in Brief

Gene therapies from Passage Bio, Locanabio; Lava’s antitumor bispecific, health disparities in Alzheimer’s and more

...Passage Bio Inc. reported that administration of PBFT02, an AAV1-GRN vector, led to elevated levels of PGRN...
...dementia caused by GRN mutations. Intra-cisterna magna injection of PBFT02 in rhesus macaques led to PGRN...
...investigate Alzheimer’s in underrepresented populations (see “NIH Taking Action”).TARGETSDMPK – Dystrophia myotonica-protein kinaseGRN – GranulinPGRN (PCDGF...
BioCentury | Aug 1, 2020
Product Development

July 31 Quick Takes: FDA approves MorphoSys’ tafasitamab; Truvian, AbbVie, Boehringer, Lilly, Alector, Henlius-Accord, Ascletis, Roche, Merck

...fallen $5.67 (27%) to $15.67 since the biotech reported Phase II data late Tuesday of PGRN...
...peptide K-Ras - KRAS PD-L1 (B7-H1; CD274) - Programmed cell death 1 ligand 1 PGRN (PCDGF...
BioCentury | May 30, 2020
Tools & Techniques

Denali offers rare peek into the science behind its CNS delivery platform

...HER2 (ERGF2; ErbB2; neu) - Epidermal growth factor receptor 2 IDS - Iduronate 2-sulfatase PGRN (PCDGF...
...Senior Editor ETV:IDS ATV:TREM2 Denali Therapeutics Inc. Takeda Pharmaceutical Co. Ltd. Triggering receptor expressed on myeloid cells 2 (TREM2) Iduronate 2-sulfatase (IDS) Progranulin (PGRN) (PCDGF)...
BioCentury | Jan 31, 2020
Financial News

Jan. 30 Financial Quick Takes: Vertex, Black Diamond, Alexion, Alector, DBV

...AL001 for frontotemporal dementia, AL002 and AL003 for Alzheimer's disease and AL101 for progranulin (PGRN; PCDGF)-related...
BioCentury | Nov 8, 2019
Emerging Company Profile

Arkuda emerges from Atlas with genetic dementia program

...issued Targets GBA (GCase) - Glucosylceramidase beta GRN - Granulin HDAC - Histone deacetylase PRGN (PCDGF...
...Progranulin SORT1 - Sortilin 1 tau (MAPT; FTDP-17) - Microtubule-associated protein τ Sandi Wong, Staff Writer Progranulin (PGRN) (PCDGF) Granulin...
BioCentury | Jul 20, 2019
Clinical News

July 19 Clinical Quick Takes: Polyphor closes Phase III murepavadin trials; plus Takeda and Alector

...tolerated, increased PGRN levels in the plasma and CSF of healthy volunteers and restored normal PGRN...
...patients in 2H19. Loss-of-function PGRN mutations are associated with neurodegeneration, and the humanized mAb increases PGRN...
...Beyond Neurons" ). Targets: GRN - Granulin; OstA (LptD; Imp) - Pseudomonas LPS-assembly protein; PGRN (PCDGF...
BioCentury | Jul 9, 2019
Company News

July 9 Company Quick Takes: Celgene, Nimbus expand deal; plus Gilead-Lyndra, Darzalex and more

...II trial of AL001 to treat FTD. AL001 is a mAb that increases levels of PGRN...
...Glucagon receptor; GLP-1 - Glucagon-like peptide-1; PD-1 (PDCD1; CD279) - Programmed cell death 1; PGRN (PCDGF...
BioCentury | Apr 19, 2019
Targets & Mechanisms

The next wave in neurodegeneration expands beyond neurons

...BCIQ: BioCentury Online Intelligence, ClinicalTrials.gov, company websites Target Company Product Indication Status Activators Progranulin (PGRN; PCDGF...
...and AL101, targeting PGRN’s degrading receptor, SORT1. Blocking the receptor increases the half-life of residual PGRN...
...Interleukin-1β IL-18 - Interleukin-18 NLRP3 (NALP3; CIAS1) - NLR family pyrin domain containing 3 PGRN (PCDGF...
BioCentury | Apr 11, 2019
Targets & Mechanisms

A venture view of biological white space

...function through programs that increase recruitment of the cells by blocking degradation of the chemokine PGRN...
...Mass. Targets CD33 (SIGLEC3) NLRP3 (NALP3; CIAS1) - NLR family pyrin domain containing 3 PGRN (PCDGF...
BioCentury | Mar 21, 2019
Emerging Company Profile

A Passage to optimal CNS vectors

...two. The second program is for the form of frontotemporal dementia (FTD) caused by loss-of-function PGRN...
...Inc., is developing a therapy for PGRN-mutant FTD. Its AL001, a humanized recombinant mAb targeting PGRN...
...β-galactosidase PGRN (PCDGF) - Progranulin Sandi Wong, Staff Writer James Wilson OrbiMed Passage Bio Inc. University of Pennsylvania Galactosidase beta 1 (GLB1) Progranulin (PGRN) (PCDGF) Neurology...
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