07:00 , Sep 4, 2014 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Prostate cancer Phosphatidylinositol-4 phosphate 5-kinase type 1a (PIP5K1A) Studies in mice and in human tissue samples suggest inhibiting PIP5K1A could help treat prostate cancer. In...
07:00 , Jul 10, 2014 |  BC Innovations  |  Targets & Mechanisms

The pain of PIP2

A team from The University of North Carolina at Chapel Hill has shown that phosphatidylinositol-4-phosphate 5-kinase type 1g regulates signaling by diverse pain receptors and has identified a small molecule antagonist that targets it. 1...
07:00 , Jul 10, 2014 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Pain Phosphatidylinositol-4-phosphate 5-kinase type 1g (PIP5K1C) Mouse studies suggest inhibiting PIP5K1C could help treat chronic pain. In mice, heterozygous knockout of Pip5k1c decreased levels of...
07:00 , May 1, 2008 |  BC Innovations  |  Distillery Therapeutics

This Week in Therapeutics

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Alzheimer's disease (AD) b-amyloid (Ab); phophatidylinositol-4,5-bisphosphate (PIP2) ; synaptojanin 1 (Synj1) Studies in cell culture and mice suggest that antagonizing Synj1...
07:00 , Mar 31, 2008 |  BioCentury  |  Regulation

EGFR pathway

EGFR pathway Vectibix panitumumab and other epidermal growth factor (EGF) receptor inhibitors are intended to prevent the growth and survival of cells that express EGFR. However, the Ras pathway is downstream of EGFR, so if...
08:00 , Feb 27, 2006 |  BioCentury  |  Product Development

Pathway complexity

Pathway complexity The rationale for developing Herceptin was straightforward: by inactivating the HER2 cell surface receptors overexpressed in certain breast cancer cells, the cascade leading to tumorigenesis can be halted. But it turned out not...