BC Innovations | May 20, 2019
Distillery Therapeutics

Analog of pleuromutilin identified for multiple cancers

DISEASE CATEGORY: Cancer INDICATION: Breast cancer; colorectal cancer; ovarian cancer; pancreatic cancer; solid tumors Cell culture and mouse studies identified a thioredoxin inhibitor that could help treat breast, ovarian, pancreatic and other cancers. Chemical synthesis...
BC Innovations | May 14, 2015
Distillery Therapeutics

Therapeutics: Procaspase-3; caspase-3 (CASP3; CPP32)

Cancer INDICATION: Cancer In vitro and mouse studies suggest metabolically stable analogs of procaspase-activating compound 1 ( PAC-1 ) could help treat cancer. PAC-1 converts procaspase-3 to CASP3 to induce cell death, but its rapid degradation via...
BC Innovations | Feb 20, 2014
Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer Procaspase-3 In vitro and mouse studies suggest combining compounds that activate procaspase-3 by different mechanisms could help treat cancer. The compound PAC-1 activates procaspase-3...
BC Innovations | Nov 12, 2009
Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer Procaspase-3; procaspase-6; caspase-3 (CASP3; CPP32); caspase-6 (CASP6; MCH2) Studies in cell culture suggest that small molecule activators of procaspases could help treat cancer. High...
BC Week In Review | Jul 30, 2007
Company News

BioLineRx, University of Illinois deal

The university granted BLRX an exclusive, worldwide license to develop and commercialize BL-4030, a preclinical apoptosis-inducing procaspase-3 activator. The timeline for Phase I testing and financial terms were not disclosed. BioLineRx Ltd. (Tel Aviv:BLRX), Jerusalem,...
BioCentury | Jul 30, 2007
Tools & Techniques

Apoptosis shortcut

Targeting proteins in the apoptotic pathway can be difficult because the pathway is often rendered nonfunctional by mutations and because many of the proteins are not specific to cancer cells, causing apoptosis in both cancerous...
BioCentury | Jul 30, 2007
Tools & Techniques

Caspase cascade

Caspase cascade By targeting procaspase-3 , BioLineRx Ltd. believes BL-4030 can bypass upstream elements in the intrinsic and extrinsic apoptosis pathways. In the intrinsic pathway, the mitochondrial membrane [1a] is depolarized due to cell stress, resulting...
BC Extra | Aug 29, 2006
Clinical News

Converting procaspase-3 to treat cancer

Researchers from the University of Illinois and colleagues published in Nature Chemical Biology the identification of PAC-1, a small molecule that converts procaspase-3 to caspase-3 and induces apoptosis in cancer cells. Caspase-3 is "the key...
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