BioCentury | Jan 15, 2019
Distillery Therapeutics

Cancer

...of aPKC correlated with poor survival. In a patient-derived angiosarcoma cell line, two tool compound PRKCD...
...viral oncogene homolog; c-Myc) and cell proliferation compared with vehicle. Next steps could include testing PRKCD...
...and Lung Research, Bad Nauheim, Germany email: st9@sanger.ac.uk Sandi Wong Max Planck Institute Atypical protein kinase C (aPKC) Protein kinase C (PKC) delta (PRKCD) Sarcoma...
BioCentury | Jul 17, 2018
Product R&D

Natural spots

...Calif. Vividion Therapeutics Inc., San Diego, Calif. Targets ACAC (ACC) - Acetyl-Coenzyme A carboxylase PKCδ (PRKCD...
BioCentury | Oct 17, 2017
Distillery Techniques

Chemistry

...PKC β (PRKCB) with K i values of 3.9 and 12 nM and PKC δ (PRKCD...
...A. Wender, Stanford University, Stanford, Calif. email: wenderp@stanford.edu Hongjiang Li Stanford University Protein kinase C (PKC) beta (PRKCB) Protein kinase C (PKC) delta (PRKCD) Protein...
BioCentury | May 23, 2017
Distillery Therapeutics

Cancer

...INDICATION: Melanoma Cell culture studies suggest inhibiting PRKCD , PKCE or RASGRP3 could help treat GNAQ...
...proliferation compared with normal PRKCD and PKCE expression. Next steps could include identifying and testing PRKCD...
...affiliation as above email: boris.bastian@ucsf.edu Hongjiang Li University of California San Francisco G protein q polypeptide (GNAQ) (G-ALPHA-q) Protein kinase C (PKC) delta (PRKCD) Protein...
BioCentury | Jul 28, 2016
Distillery Therapeutics

Therapeutics: Protein kinase C δ (PRKCD)

...Neurology INDICATION: Pain Mouse studies suggest inhibiting PRKCD could help treat chronic pain associated with sickle...
...model of SCD expressing mutant human hemoglobin, a PRKCD inhibitor tool compound or siRNA targeting PRKCD...
...testing pharmacological inhibitors of PRKCD in models of SCD-associated pain. TARGET/MARKER/PATHWAY: Protein kinase C δ (PRKCD...
BioCentury | Aug 27, 2015
Distillery Therapeutics

Therapeutics: FYN proto-oncogene src family tyrosine kinase (FYN); protein kinase C (PKC) δ (PRKCD)

...TARGET/MARKER/PATHWAY: FYN proto-oncogene src family tyrosine kinase (FYN) ; protein kinase C (PKC) δ ( PRKCD...
BioCentury | Mar 12, 2015
Distillery Therapeutics

Therapeutics: Protein kinase C (PKC) α (PRKCA); PKC δ (PRKCD); PKC θ (PRKCQ)

...treat Hodgkin's disease. TARGET/MARKER/PATHWAY: Protein kinase C (PKC) α ( PRKCA ); PKC δ ( PRKCD...
BioCentury | Jul 18, 2013
Distillery Therapeutics

Indication: Infectious disease

...Infectious disease HIV/AIDS Protein kinase Cd (PRKCD) In vitro studies suggest analogs of prostratin, a PRKCD...
...infection. Chemical synthesis and in vitro testing of prostratin analogs identified multiple compounds that inhibited PRKCD...
BioCentury | Nov 10, 2011
Distillery Therapeutics

Indication: Neurology

...contact information Neurology Huntington's disease (HD) Huntingtin (HTT); ataxia telangiectasia mutated (ATM); protein kinase Cd (PRKCD...
...than that in cells expressing wild-type HTT. In these cells, an inhibitor of ATM or PRKCD...
BioCentury | Jun 9, 2011
Distillery Therapeutics

Indication: Cancer

...and contact information Cancer Cancer Protein kinase Cd (PRKCD) In vitro and mouse studies suggest PRKCD...
...rat renal proximal tubule cell line and in the kidneys of normal mice, cisplatin upregulated Prkcd...
...activity compared with no treatment. In mouse models of cisplatin-induced renal toxicity and cisplatin-treated cancers, PRKCD...
Items per page:
1 - 10 of 29