BioCentury | Jun 26, 2020
Distillery Therapeutics

Increasing PXR activity to treat acute kidney injury

...damage Promoting the activity of the transcription factor PXR could treat acute kidney injury (AKI). PXR...
...compound or overexpression of PXR or AKR1B7 -- a rodent ortholog of human AKR1B10 that PXR...
...model of cisplatin-induced AKI, intraperitoneal injection of the PXR agonist or tail vein injection of PXR...
BioCentury | May 31, 2017
Distillery Techniques

Disease models

...AHR) , constitutive androstane receptor ( NR1I3 ; CAR), liver X receptor (LXR) , pregnane X receptor (PXR...
...NR1I3) (CAR) Cytochrome P450 Epidermal growth factor (EGF) Liver X receptor (LXR) Noggin (NOG) Peroxisome proliferation activated receptor (PPAR) alpha Pregnane X receptor (PXR) R-Spondin...
BioCentury | Nov 2, 2016
Distillery Techniques

Disease models

...TECHNOLOGY: Transgenics and knockouts Transgenic mice expressing human PXR , NR1I3 , CYP3A4 and CYP2D6 could...
...model to test a wide variety of drug-drug interactions. DESCRIPTION: Transgenic mice expressing human pregnane X receptor (PXR...
BioCentury | Jan 7, 2016
Distillery Therapeutics

Therapeutics: Pregnane X receptor (PXR)

...Liver disease Cell culture and mouse studies suggest an extract of Schisandra sphenanthera that agonizes PXR...
...of the extract's six bioactive components (schisandrins and schisandrols) and a different PXR agonist induced PXR...
...effects of the extract's individual components on liver cell proliferation and liver regeneration. TARGET/MARKER/PATHWAY: Pregnane X receptor (PXR...
BioCentury | Feb 6, 2014
Distillery Techniques

Technology: Disease models

...2 diabetes Transgenic mice expressing human PXR could be used to study the role of PXR...
...drugs to treat the indication. In mice fed a high-fat diet, transgenic expression of human PXR...
...diabetes and decreased obesity compared with wild-type mouse Pxr expression. Future studies could include assessing PXR...
BioCentury | Aug 4, 2011
Tools & Techniques

Metabolically, man or mouse

...model using a targeted insertion strategy to humanize four genes involved in drug metabolism: pregnane X receptor (PXR...
BioCentury | Jun 16, 2011
Distillery Therapeutics

Indication: Inflammatory disease

...and contact information Inflammatory disease Colitis Pregnane X receptor (PXR) Mouse studies suggest a class of steroid PXR...
...of steroid PXR agonists could help treat colitis. In PXR-expressing mouse models of colitis, the PXR...
BioCentury | Mar 12, 2007
Company News

CXR, Millipore sales and marketing update

...P450 2D6 (CYP2D6) , cytochrome P450 2A6 (CYP2A6) ; cytochrome P450 reductase (CYPR) ; pregnane X receptor (PXR...
BioCentury | Jun 18, 2001
Company News

GlaxoSmithKline other research news

...GSK and colleagues published in Nature the structural basis for the ability of PXR , a...
...the authors said. GlaxoSmithKline plc (GSK; LSE:GSK), London, U.K., et al. Product: Structure of human pregnane X receptor...
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