The most recent Phase III data from a heart failure candidate may have been underwhelming, but a look at the broader pipeline suggests the long period of drought in innovation could soon give way to...

DISEASE CATEGORY: Cancer INDICATION: Gastric cancer Interrupting the interaction between PP2A catalytic subunit PPP2CA and STRN3, a regulatory subunit, could treat gastric cancer. In patients, STRN3 expression...

If and when Americans are vaccinated against COVID-19, they might take a moment to thank another virus, H1N1 influenza. The country’s poor response to an H1N1 outbreak in 2009, including vaccine delays and shortages caused...

As the world eyes a return to post-COVID crisis “normalcy,” a robust global recovery will depend on effective treatments and ultimately a vaccine. Yes, more than 400 research and clinical programs are already under way,...

Lawyers have identified workarounds that allow venture-backed biotechs to comply with Small Business Administration affiliation rules to access an emergency forgivable loan program for small businesses created by the Coronavirus Aid, Relief, and Economic Security...

Venture-backed companies may be shut out of an emergency forgivable loan program for small businesses created by the Coronavirus Aid, Relief, and Economic Security (CARES) Act unless the Trump administration takes urgent action to modify...

The idea of sending disease-driving proteins to the cell’s garbage can is only the first act in a field that now centers around targeted degradation. In the sequel, researchers are extending the principle to other...

INDICATION: Multiple sclerosis (MS) Mouse studies suggest inhibiting PP2A could help treat MS. In the experimental autoimmune encephalomyelitis (EAE) mouse model of MS, T cell-specific knockout of PP2A or the terpenoid toxin cantharidin, which inhibits...

New Therapeutic Targets and Biomarkers: August 2018 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database in August 2018. Therapeutic targets are defined as any protein, gene or other...

Neoantigens derived from alternative splicing could broaden the target space for cancer vaccines and T cell therapies, according to two studies published this month. While questions remain about whether they are sufficiently immunogenic to create...